David Artis, PhD
David Artis, Ph.D.
Michael Kors Professor of Immunology, Department of Medicine
Professor of Microbiology and Immunology, Department of Microbiology and Immunology
Director, Jill Roberts Institute for Research in Inflammatory Bowel Disease
Director, Friedman Center for Nutrition and Inflammation
Co-Director, Allen Discovery Center for Neuroimmune Interactions
413 E 69th Street, BB-709
New York, NY 10022- Office: (646) 962-6312
- Web: artislab.weill.cornell.edu
- Administrative Assistant
Magdalena Fuentes
Email: artisadmin@med.cornell.edu - Research Project Manager
Kimbeliza Ocasio-Altreche, M.A.
Email: kio2004@med.cornell.edu
Focus
The goals of the Artis lab are to understand the regulatory mechanisms that control immune cell homeostasis at the body's barrier surfaces. Employing diverse models of microbial colonization, pathogen infection and chronic inflammation, research in the Artis lab is examining how mammalian host genetics and signals derived from commensal microbial communities influence innate and adaptive immune responses in the skin, lung and intestine.
Ongoing studies are examining the influence of host genetic- and environmental-derived signals on the development and functions of innate and adaptive immune cells in the context of health and disease. The findings of these studies offer the potential to identify new therapeutic targets to limit infection, chronic inflammation and autoimmune diseases.
MIST Research
The immune system at mucosal sites must be tightly regulated to mediate rapid immunity to invading pathogens, while limiting over-reactive responses that drive chronic inflammation. In particular, type 2 immune responses in the airway or gastrointestinal tract are essential to protect from helminth parasites, but if dysregulated, drive asthma and allergic inflammation. Despite this knowledge, we do not yet fully appreciate the complexity of cellular and molecular signals that control these responses, which will be critical for developing the next generation of preventative, therapeutic or curative treatments. The fundamental focus of this renewal application for the Mucosal Immunology Studies Team is to define novel pathways by which the type 2 immune response harnesses signals associated with the nervous system to regulate rapid mucosal immunity and inflammation. In this context, we will define: (i) the pathways that induce and regulate these neuronal signals, (ii) the functional significance of these pathways in type 2 mucosal immunity and inflammation, and (iii) whether it is possible to therapeutically target these signals to boost immunity to helminth infection or reduced chronic allergic inflammation. We will employ innovative approaches and develop new tools to address these fundamental gaps in knowledge, and where possible, translate our findings from mice into humans. Results from these studies will significantly advance our understanding of the pathways that are essential to mediate rapid immunity and inflammation at mucosal sites and could provoke the next generation of preventative, therapeutic and curative treatment strategies.
Current Grant Support
Research in the Artis lab is supported by the National Institutes of Health (DK126871, AI151599, AI095466, AI095608, AR070116, AI172027, DK132244 all to D.A.), the Crohn's and Colitis Foundation, CURE for IBD, the Sanders Family Foundation, the Rosanne H. Silbermann Foundation and the WCM Jill Roberts Institute for Research in IBD.
Publications
David Artis, PhD
Arifuzzaman M, Collins N, Guo CJ, Artis D. Nutritional regulation of microbiota-derived metabolites: Implications for immunity and inflammation. Immunity. 2024 Jan 9;57(1):14-27. doi: 10.1016/j.immuni.2023.12.009.PMID: 38198849 Review.
Arifuzzaman M, Won TH, Yano H, Uddin J, Emanuel ER, Hu E, Zhang W, Li TT, Jin WB, Grier A, Kashyap S; JRI Live Cell Bank; Guo CJ, Schroeder FC, Artis D. Dietary fiber is a critical determinant of pathologic ILC2 responses and intestinal inflammation. J Exp Med. 2024 May 6;221(5):e20232148. doi: 10.1084/jem.20232148. Epub 2024 Mar 20.PMID: 38506708
Emanuel E, Arifuzzaman M, Artis D. Epithelial-neuronal-immune cell interactions: Implications for immunity, inflammation, and tissue homeostasis at mucosal sites. J Allergy Clin Immunol. 2024 May;153(5):1169-1180. doi: 10.1016/j.jaci.2024.02.004. Epub 2024 Feb 16.PMID: 38369030 Review.
Arifuzzaman M, Won TH, Li TT, Yano H, Digumarthi S, Heras AF, Zhang W, Parkhurst CN, Kashyap S, Jin WB, Putzel GG, Tsou AM, Chu C, Wei Q, Grier A; JRI IBD Live Cell Bank Consortium; Worgall S, Guo CJ, Schroeder FC, Artis D. Inulin fibre promotes microbiota-derived bile acids and type 2 inflammation. Nature. 2022 Nov;611(7936):578-584. doi: 10.1038/s41586-022-05380-y. Epub 2022 Nov 2.PMID: 36323778
Zhang W, Lyu M, Bessman NJ, Xie Z, Arifuzzaman M, Yano H, Parkhurst CN, Chu C, Zhou L, Putzel GG, Li TT, Jin WB, Zhou J; JRI Live Cell Bank; Hu H, Tsou AM, Guo CJ, Artis D. Gut-innervating nociceptors regulate the intestinal microbiota to promote tissue protection. Cell. 2022 Oct 27;185(22):4170-4189.e20. doi: 10.1016/j.cell.2022.09.008. Epub 2022 Oct 14.PMID: 36240781
Tamari M, Del Bel KL, Ver Heul AM, Zamidar L, Orimo K, Hoshi M, Trier AM, Yano H, Yang TL, Biggs CM, Motomura K, Shibuya R, Yu CD, Xie Z, Iriki H, Wang Z, Auyeung K, Damle G, Demircioglu D, Gregory JK, Hasson D, Dai J, Chang RB, Morita H, Matsumoto K, Jain S, Van Dyken S, Milner JD, Bogunovic D, Hu H, Artis D, Turvey SE, Kim BS. Sensory neurons promote immune homeostasis in the lung. Cell. 2024 Jan 4;187(1):44-61.e17. doi: 10.1016/j.cell.2023.11.027. Epub 2023 Dec 21.PMID: 38134932
Kim B, Rothenberg ME, Sun X, Bachert C, Artis D, Zaheer R, Deniz Y, Rowe P, Cyr S. Neuroimmune interplay during type 2 inflammation: Symptoms, mechanisms, and therapeutic targets in atopic diseases. J Allergy Clin Immunol. 2024 Apr;153(4):879-893. doi: 10.1016/j.jaci.2023.08.017. Epub 2023 Aug 25.PMID: 37634890
Wheeler MA, Clark IC, Lee HG, Li Z, Linnerbauer M, Rone JM, Blain M, Akl CF, Piester G, Giovannoni F, Charabati M, Lee JH, Kye YC, Choi J, Sanmarco LM, Srun L, Chung EN, Flausino LE, Andersen BM, Rothhammer V, Yano H, Illouz T, Zandee SEJ, Daniel C, Artis D, Prinz M, Abate AR, Kuchroo VK, Antel JP, Prat A, Quintana FJ. Droplet-based forward genetic screening of astrocyte-microglia cross-talk. Science. 2023 Mar 10;379(6636):1023-1030. doi: 10.1126/science.abq4822. Epub 2023 Mar 9.PMID: 36893254
Jarick KJ, Topczewska PM, Jakob MO, Yano H, Arifuzzaman M, Gao X, Boulekou S, Stokic-Trtica V, Leclère PS, Preußer A, Rompe ZA, Stamm A, Tsou AM, Chu C, Heinrich FR, Guerra GM, Durek P, Ivanov A, Beule D, Helfrich S, Duerr CU, Kühl AA, Stehle C, Romagnani C, Mashreghi MF, Diefenbach A, Artis D, Klose CSN. Non-redundant functions of group 2 innate lymphoid cells. Nature. 2022 Nov;611(7937):794-800. doi: 10.1038/s41586-022-05395-5. Epub 2022 Nov 2.PMID: 36323785
Tsou AM, Yano H, Parkhurst CN, Mahlakõiv T, Chu C, Zhang W, He Z, Jarick KJ, Zhong C, Putzel GG, Hatazaki M; JRI IBD Live Cell Bank Consortium; Lorenz IC, Andrew D, Balderes P, Klose CSN, Lira SA, Artis D. Neuropeptide regulation of non-redundant ILC2 responses at barrier surfaces. Nature. 2022 Nov;611(7937):787-793. doi: 10.1038/s41586-022-05297-6. Epub 2022 Nov 2.PMID: 36323781
Jin WB, Li TT, Huo D, Qu S, Li XV, Arifuzzaman M, Lima SF, Shi HQ, Wang A, Putzel GG, Longman RS, Artis D, Guo CJ. Genetic manipulation of gut microbes enables single-gene interrogation in a complex microbiome. Cell. 2022 Feb 3;185(3):547-562.e22. doi: 10.1016/j.cell.2021.12.035. Epub 2022 Jan 19.PMID: 35051369
Yano H, Artis D. Neuronal regulation of innate lymphoid cell responses. Curr Opin Immunol. 2022 Jun;76:102205. doi: 10.1016/j.coi.2022.102205. Epub 2022 May 12.PMID: 35569418 Review.
Topczewska PM, Rompe ZA, Jakob MO, Stamm A, Leclère PS, Preußer A, Duerr CU, Thole LML, Kotsch K, Artis D, Klose CSN. ILC2 require cell-intrinsic ST2 signals to promote type 2 immune responses.Front Immunol. 2023 Mar 31;14:1130933. doi: 10.3389/fimmu.2023.1130933. eCollection 2023.PMID: 37063913
Zaiss DMW, Pearce EJ, Artis D, McKenzie ANJ, Klose CSN. Cooperation of ILC2s and TH2 cells in the expulsion of intestinal helminth parasites. Nat Rev Immunol. 2024 Apr;24(4):294-302. doi: 10.1038/s41577-023-00942-1. Epub 2023 Oct 5.PMID: 37798539 Review.
Irie M, Sasahara K, Artis D, Kabata H. Current overview of the role of neuropeptides in ILC2s and future directions. Allergol Int. 2022 Jul;71(3):294-300. doi: 10.1016/j.alit.2022.03.002. Epub 2022 Mar 30.PMID: 35367135 Free article. Review.
Arifuzzaman M, Won TH, Li TT, Yano H, Digumarthi S, Heras AF, Zhang W, Parkhurst CN, Kashyap S, Jin WB, Putzel GG, Tsou AM, Chu C, Wei Q, Grier A, JRI IBD Live Cell Bank Consortium, Worgall S, Guo CJ, Schroeder FC, Artis D. Inulin fiber promotes microbiota-derived bile acids and type 2 inflammation. Nature 2022 Nov;611(7936):578-584. doi: 10.1038/s41586-022-05380-y. Epub 2022 Nov 2. PMID: 36323778.
Tsou AM, Yano H, Parkhurst CN1, Mahlakõiv T, Chu C, Zhang W, He Z, Jarick KJ, Zhong C, Putzel GG, Hatazaki M, JRI IBD Live Cell Bank Consortium, Lorenz IC, Andrew D, Balderes P, Klose CSN, Lira SA, Artis D. Neuropeptide regulation of non-redundant ILC2 responses at barrier surfaces. Nature 2022 Nov;611(7937):787-793. doi: 10.1038/s41586-022-05297-6. Epub 2022 Nov 2. PMID: 36323781.
Zhang W, Lyu M, Bessman NJ, Xie Z, Arifuzzaman M, Yano H, Parkhurst CN, Chu C, Zhou L, Putzel GG, Li TT, Jin WB, Zhou J, JRI Live Cell Bank, Hu H, Tsou AM, Guo CJ, Artis D. Gut-innervating nociceptors regulate the intestinal microbiota to promote tissue protection. Cell 2022 Oct 27;185(22):4170-4189.e20. doi: 10.1016/j.cell.2022.09.008. Epub 2022 Oct 14. PMID: 36240781.
Chu C, Parkhurst CN, Zhang W, Zhou L, Yano H, Arifuzzaman M, Artis D. The ChAT-acetylcholine pathway promotes group 2 innate lymphoid cell responses and anti-helminth immunity. Sci Immunol. 2021 Mar 5;6(57):eabe3218. doi: 10.1126/sciimmunol.abe3218. PMID: 33674322
Chung H, Parkhurst CN, Magee EM, Phillips D, Habibi E, Chen F, Yeung BZ, Waldman J, Artis D, Regev A. Joint single-cell measurements of nuclear proteins and RNA in vivo. Nat Methods. 2021 Oct;18(10):1204-1212. doi: 10.1038/s41592-021-01278-1. Epub 2021 Oct 4. PMID: 34608310
Kabata H, Flamar AL, Mahlakõiv T, Moriyama S, Rodewald HR, Ziegler SF, Artis D. Targeted deletion of the TSLP receptor reveals cellular mechanisms that promote type 2 airway inflammation. Mucosal Immunol. 2020 Jul;13(4):626-636. doi: 10.1038/s41385-020-0266-x. Epub 2020 Feb 17. PMID: 32066836
Flamar AL, Klose CSN, Moeller JB, Mahlakõiv T, Bessman NJ, Zhang W, Moriyama S, Stokic-Trtica V, Rankin LC, Putzel GG, Rodewald HR, He Z, Chen L, Lira SA, Karsenty G, Artis D. Interleukin-33 Induces the Enzyme Tryptophan Hydroxylase 1 to Promote Inflammatory Group 2 Innate Lymphoid Cell-Mediated Immunity. Immunity. 2020 Apr 14;52(4):606-619.e6. doi: 10.1016/j.immuni.2020.02.009. Epub 2020 Mar 10. PMID: 32160524.
Monticelli LA, Diamond JM, Saenz SA, Tait Wojno ED, Porteous MK, Cantu E, Artis, D, Christie JD. Innate Lymphoid Cell Composition Is Altered in Primary Graft Dysfunction. Am J Respir Crit Care Med. 2020 Jan 1;201(1):63-72. doi: 10.1164/rccm.201906-1113OC. PMID: 31394048
Review Journals
Klose CSN, Artis D. Innate lymphoid cells control signaling circuits to regulate tissue-specific immunity. Cell Res. 2020 Jun; 30(6): 475 -491. Doi: 10.1038/s41422-020-0323-8. Epub 2020 May 6. PMID: 32376911.
Chu C, Artis D, Chiu IM. Neuro-immune Interactions in the Tissues. Immunity. 2020 Mar 17;52(3):464-474. doi: 10.1016/j.immuni.2020.02.017.PMID: 32187517.