Publications

  1. Home
  2. Publications
  3. Boris Striepen, PhD

Publications

Boris Striepen, PhD

Pardy, R. D. et al. Analysis of intestinal epithelial cell responses to Cryptosporidium highlights the temporal effects of IFN-gamma on parasite restriction. PLoS Pathog 20, e1011820 (2024).

Wallbank, B., Pardy, R. D., Brodsky, I. E., Hunter, C. A. & Striepen, B. Cryptosporidium impacts epithelial turnover and is resistant to induced cell death. mBio in press (2024).

Walzer, K. A. et al. Transcriptional control of the Cryptosporidium life cycle. Nature (2024).

Cohn, I. S., Henrickson, S. E., Striepen, B. & Hunter, C. A. Immunity to Cryptosporidium: Lessons from Acquired and Primary Immunodeficiencies. J Immunol 209, 2261-2268 (2022).

Cohn, I. S. et al. Intestinal cDC1s provide cues required for CD4+ T cell-mediated resistance to Cryptosporidium. J Exp Med 221 (2024).

Haskins, B. E. et al. Dendritic cell-mediated responses to secreted Cryptosporidium effectors promote parasite-specific CD8(+) T cell responses. Mucosal Immunol 17, 387-401 (2024).

Pardy, R. D., Wallbank, B. A., Striepen, B. & Hunter, C. A. Immunity to Cryptosporidium: insights into principles of enteric responses to infection. Nat Rev Immunol 24, 142-155 (2024).

Gibson A.R., Sateriale A., Dumaine J.E., Engiles J.B., Pardy R.D., Gullicksrud J.A., O'Dea, K., Beiting, D. P., Hunter, C.A., and Striepen, B. (2022) A genetic screen identifies a protective type III interferon response to Cryptosporidium that requires TLR3 dependent recognition. PLoS Pathogens 18: e1010003.

English, E.D., Guerin, A, Tandel, J. and Striepen, B. (2022) Live imaging of the Cryptosporidium parvum lifecycle reveals direct development of male and female gametes from type I meronts. PLoS Biology 20: e3001604.

Dumaine, J.E., Sateriale, A., Gibson, A.R., Redy, A., Gullicksrud, J.A., Hunter, E., and Striepen, B. (2021) The enteric pathogen Cryptosporidium parvum exports proteins into the cytosol of the infected host cell. eLife. e70451.

Gullicksrud, J.A., Sateriale, A., Engiles, J.B., Gibson, A., Shaw, S., Hutchins, Z.A., Martin, L., Christian, D., Taylor, G.A., Yamamoto, M., Beiting, D.P., Striepen, B., and Hunter, C.A. (2022) Crosstalk between enterocytes and innate lymphoid cell drives early IFN-γ-mediated control of Cryptosporidium. Mucosal Immunity 15: 362-372.

Guérin, A., Roy, N.H., Kugler, E.M., Berry, L., Burkhardt, J.K., Shin, J.-B., and Striepen, B. (2021) A screen for Cryptosporidium rhoptry proteins identifies ROP1 as an effector targeting the host cytoskeletal modulator LMO7. Cell Host & Microbe 29: 1-14.

Sateriale, A., Gullicksrud, J.A., Engiles, J.B., McLeod, B., Kugler, E.M., Henao-Mejia, J., Zhou, T., Ring, A.M., Brodsky, I.E., J.C. Hunter, C.A., and Striepen, B. (2021) The intestinal parasite Cryptosporidium is controlled by an enterocyte intrinsic inflammasome that depends on NLRP6. Proc. Natl. Acad. Sci. U.S.A. 118: e2007807118.

Guérin, A., and Striepen, B. (2020) The Biology of the intestinal intracellular parasite Cryptosporidium. Cell Host & Microbe 28: 509-515.

Vinayak, S., Jumani, R.S., Miller, P., Hasan, M.M., McLeod, B., Tandel, J., Stebbins, E.E., Teixeira, J.E., Borrel, J., Gonse, A., Zhang, M., Yu, X., Wernimont, A., Walpole, C., Eckley, S., Love, M.S., McNamara, C. W., Sharma, M., Sharma, A., Kato, N., Schreiber, S.L., Melillo, B., Striepen*, B., Huston*, C.D., and Comer*, E. (2020) Phenylalanyl-tRNA synthetase (PheRS), a novel drug target for Cryptosporidium: discovery of therapeutically relevant inhibitors with genetic, biochemical and chemical target validation. *co-corresponding authors. Science Transl. Med. 12, eaba8412

Pawlowic, M., Somepalli, M., Sateriale, A., Herbert, G.T. Gibson, A.R., Cuny, G., Hedstrom, L., and Striepen, B. (2019) Genetic ablation of purine salvage in Cryptosporidium parvum reveals nucleotide uptake from the host cell. Proc. Natl. Acad. Sci. U.S.A. 116: 21160-21165.

Tandel, J., English, E., Sateriale, A., Gullicksrud, J., Beiting, D.P., Sullivan, M.C., Pinkston, B., and Striepen, B. (2019) Lifecycle progression and sexual development of the apicomplexan parasite Cryptosporidium parvum. Nature Microbiology 4: 2226-2236

Sateriale, A., Slapeta, J., Baptista, R., Engiles, J.B., Gullicksrud, J.A., Herbert, G.T., Brooks, C.F., Kugler, E.M., Kissinger, J.C. Hunter, C.A., and Striepen, B. (2019) A genetically tractable, natural mouse model of cryptosporidiosis offers insights into host protective immunity. Cell Host & Microbe 26, 135–146

Manjunatha, U.H.†, Vinayak, S.†, Zambriski, J.A.*†, Chao, A.T., Sy, T., Noble, S.J., Bonamy, G., Kondreddi, R.R., Zou, B., Gedeck, P., Brooks, C.F., Herbert, G.T., Sateriale, A., Tandel, J., Noh, S., Lakshminarayana, S.B., Lim, S.H., Goodman, L.B., Yeung, B.K.S., Bodenreider, C., Feng, G., Zhang, L., Blasco, F., Wagner, J., Leong. F.J., Striepen, B.*, and Diagana T. * (2017) An inhibitor of the Cryptosporidium PI(4)K is a candidate drug for cryptosporidiosis. Nature 546: 376-380 (*equal contribution)

Vinayak, S.*, Pawlowic, M.C.*, Sateriale, A*, Brooks, C.F., Studstill, J.C., Bar-Peled, Y., Cirpriano, M.J. and Striepen, B. (2015) Genetic modification of the diarrheal pathogen Cryptosporidium parvum. Nature 523: 477–480 (*equal contribution)

Photo: Immunofluorescence photomicrograph demonstrating the intestinal niche of Nippostrongylus brasiliensis, a hookworm that colonizes the mouse gut and is used to model gastrointestinal nematode infections in humans. Photo Credit: Herbert laboratory, University of Pennsylvania School of Veterinary Medicine.