Current Pilot Project Grant Recipients

2018 Grant Recipients

Impact of Gnotobiosis, Bacterial Metabolomics and Nutrition on Mucosal Immune Cells Pilot Projects

Purpose: To solicit applications for proposed research studies that advance our understanding of immune defense mechanisms and immune regulation at the mucosal surfaces in one of three major areas: a) understanding the impact of microbiota on mucosal immunity using gnotobiotic mice, b) investigating the effects of nutrition on mucosal immune responses, or c) examining how bacterial metabolites can impact mucosal defense mechanisms, including epithelial and immune mediated responses. Full or partial funds were distributed to the most meritorious applications.

Awardees being finalized now.

MIST Scholar Award in Mucosal Immunity

Purpose: To encourage early stage scientists and/or clinicians to pursue careers in understanding immune defense mechanisms and immune regulation at mucosal surfaces, including respiratory, gastrointestinal and urogenital tract mucosa. A long-term goal of the Mucosal Immunology Studies Team (MIST) is to contribute to the knowledge base needed to facilitate future development of vaccines and immunotherapies to protect mucosal surfaces from infection and immune-mediated pathology. High emphasis was placed on proposed studies that intended to provide a more sophisticated understanding of mucosal immune defense mechanisms, explore novel hypotheses, or address difficult unsolved questions in mucosal immunity and that have the capacity to develop into independently supported projects.

2017 Grant Recipients

Innovative Collaborations in Mucosal Immunology Pilot Projects

Purpose: To solicit applications for proposed research studies that break new ground in understanding of immune defense mechanisms and immune regulation at the mucosal surfaces, by promoting innovative collaborations among MIST investigators that either 1) foster interactions and scientific dialogue between MIST investigators or 2) bring in outside investigators that will enrich, and benefit the goals of, the MIST consortium. Full or partial funds were distributed to the most meritorious applications.

Title of Application Co-PI's Institution
Role of the gut mucosal barrier in restricting the uropathogenic E. coli gastrointestinal reservoir Hultgren, Scott Washington University
Hansson, Gunnar Göteborg University (Sweden)
Interactions between ILC3 and mucosal CD4 T cells Sonnenberg, Gregory Weill Medical College of Cornell 
Cheroutre, Hilde La Jolla Institute For Allergy & Immunology
TNF superfamily receptors control ILC2 responses Kronenberg, Mitch La Jolla Institute For Allergy & Immunology
Artis, David & Sonnenberg, Gregory Weill Medical College of Cornell 
Mucus produced by Paneth cells, a role for crypt protection Johansson, Malin & Hansson, Gunnar Göteborg University (Sweden)
Bevins, Charles   University of California at Davis
A role for RIP1K in mucosal T cells Cheroutre, Hilde La Jolla Institute For Allergy & Immunology
Kronenberg, Mitch La Jolla Institute For Allergy & Immunology
Structural basis of microbiota recognition by polyreactive intestinal IgA Bendelac, Albert University of Chicago
Adams, Erin University of Chicago
Activation of asthma by airway microfold cells Shiloh, Michael UT Southwestern Medical Center
Pasare, Chandrashekhar UT Southwestern Medical Center
Exposure to house dust mite accelerates lung cancer Raz, Eyal University of California at San Diego
Broide, David University of California at San Diego

Learn more:

Pilot Project Overview
Application Instructions
Past Grant Recipients
Frequently Asked Questions

Photo: Color enhanced histologic image showing intestinal tissue damage in a murine model of intestinal inflammation. Photo Credit: Artis and Sonnenberg laboratories, Weill Cornell Medical College.