Chuck Bevins

Chairatana P, Chu H, Castillo PA, Shen B, Bevins CL, Nolan EM. Proteolysis Triggers Self-Assembly and Unmasks Innate Immune Function of a Human α-Defensin Peptide. Chem Sci. 2016 Mar 1;7(3):1738-1752. doi: 10.1039/C5SC04194E. Epub 2015 Dec 10. PubMed PMID: 27076903; PubMed Central PMCID: PMC4827351.

Clevers HC, Bevins CL. Paneth cells: maestros of the small intestinal crypts.  Annu Rev Physiol. 2013;75: 289-311. doi: 10.1146/annurev-physiol-030212-183744. Review. PubMed PMID: 23398152.

Chu H, Pazgier M, Jung G, Nuccio SP, Castillo PA, de Jong MF, Winter MG, Winter SE, Wehkamp J, Shen B, Salzman NH, Underwood MA, Tsolis RM, Young GM, Lu W, Lehrer RI, Bäumler AJ, Bevins CL. Human α-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets. Science. 2012 Jul 27;337(6093):477-81. doi: 10.1126/science.1218831. Epub 2012 Jun 21. PubMed PMID: 22722251; PubMed Central PMCID: PMC4332406.

Wehkamp J, Salzman NH, Porter E, Nuding S, Weichenthal M, Petras RE, Shen B, Schaeffeler E, Schwab M, Linzmeier R, Feathers RW, Chu H, Lima H Jr, Fellermann K, Ganz T, Stange EF, Bevins CL. Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18129-34. Epub 2005 Dec 5. PubMed PMID: 16330776; PubMed Central PMCID: PMC1306791.

Photo: Immunofluorescence photomicrograph demonstrating the intestinal niche of Nippostrongylus brasiliensis, a hookworm that colonizes the mouse gut and is used to model gastrointestinal nematode infections in humans. Photo Credit: Herbert laboratory, University of Pennsylvania School of Veterinary Medicine.