Publications

Gwendalyn J. Randolph, PhD.

Uzzan M, Martin JC, Mesin L, Livanos AE, Castro-Dopico T, Huang R, Petralia F, Magri G, Kumar S, Zhao Q, Rosenstein AK, Tokuyama M, Sharma K, Ungaro R, Kosoy R, Jha D, Fischer J, Singh H, Keir ME, Ramamoorthi N, Gorman WEO, Cohen BL, Rahman A, Cossarini F, Seki A, Leyre L, Vaquero ST, Gurunathan S, Grasset EK, Losic B, Dubinsky M, Greenstein AJ, Gottlieb Z, Legnani P, George J, Irizar H, Stojmirovic A, Brodmerkel C, Kasarkis A, Sands BE, Furtado G, Lira SA, Tuong ZK, Ko HM, Cerutti A, Elson CO, Clatworthy MR, Merad M, Suárez-Fariñas M, Argmann C, Hackney JA, Victora GD, Randolph GJ, Kenigsberg E, Colombel JF, Mehandru S. Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity. Nat Med. 2022 Apr;28(4):766-779. doi: 10.1038/s41591-022-01680-y.

Czepielewski RS., Erlich EC., Onufer EJ., Young S, Saunders BT, Han YH, Wohltmann M, Wang PL, Kim KW, Kumar S, Hsieh CS, Scallan JP, Yang Y, Zinselmeyer BH, Davis MJ, Randolph GJ. 2021. Ileitis-associated mesenteric tertiary lymphoid organs arise at lymphatic valves and impede lymph flow in response to tumor necrosis factor. Immunity, 54(12):2795-2811. doi: 10.1016/j.immuni.2021.10.003. PMCID: 8678349

Zhang N, Kim SH, Gainullina A, Erlich EC, Onufer EJ, Kim J, Czepielewski RS, Helmink BA, Dominguez JR, Saunders BT, Ding J, Williams JW, Jiang JX, Segal BH, Zinselmeyer BH, Randolph GJ, Kim KW. 2021. LYVE1hi macrophages reside in mesothelium and promote omentum-independent ovarian tumor growth in the peritoneum. J. Exp. Med., 218(12):e20210924. doi: 10.1084/jem.20210924. *joint senior author; ^primary corresponding author. PMCID: 8575007

Han YH, Onufer EJ, Sprung RW, Davidson WS, Czepielewski RS, Wohltmann M, Sorci-Thomas MG, Warner BW, Randolph GJ. 2021. Enterically derived high-density lipoprotein restrains liver injury through the portal vein. Science, 373, 410; DOI: 10.1126/science.abe6729. [Feature articles in Immunity, and Nature Rev Gastro Hepatol]

Baba O, Elvington A, Sultan D, Heo GS, Zhang X, Luehmann H, Detering L, Szpakowska M, Chevigne A, Liu Y, Randolph GJ. 2021. CXCR4 on atherosclerotic plaque endothelium predicts the magnitude of monocyte recruitment and is readily targeted by PET tracers. Arterio Thromb Vasc Biol 41(2):822-836. doi: 10.1161/ATVBAHA.120.315053. [editorial comment, same issue]

Huang LH, Deepak P, Ciorba MA, Mittendorfer B, Patterson BW, Randolph GJ. 2020. Postprandial chylomicron output and transport through intestinal lymphatics are not impaired in active Crohn's disease. Gastroenterology, 159:1955-9156. doi: 10.1053/j.gastro.2020.07.012. [letter to the editor published, along with our reply, April 2021]

Williams JW, Zaitsev K, Kim KW, Ivanov S, Saunders BT, Schrank PR, Kim K, Elvington A, Kim SH, Tucker C, Wohltmann M, Fife BT, Epelman S, Artyomov M, Lavine KJ, Zinselmeyer BH, Choi JH, Randolph GJ. Limited proliferation capacity of aorta intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression. Nature Immunology, 21:1194-1204. doi. 10.1038/s41590-020-0768-4

Photo: Immunofluorescence photomicrograph demonstrating the intestinal niche of Nippostrongylus brasiliensis, a hookworm that colonizes the mouse gut and is used to model gastrointestinal nematode infections in humans. Photo Credit: Herbert laboratory, University of Pennsylvania School of Veterinary Medicine.