MIST - Mucosal Immunology Studies Team
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Mucosal Immunology Studies Team (MIST) - Improving Understanding of Mucosal Immunity MIST: Improving Understanding of Mucosal Immunity
Mucosal Immunology Studies Team (MIST) - Improving Understanding of Mucosal Immunity About MIST MIST: Pilot Project MIST: Project Investigators MIST: Publications & Resources Contact MIST Mucosal Immunology Studies Team (MIST) - Improving Understanding of Mucosal Immunity
Mucosal Immunology Studies Team (MIST) - Improving Understanding of Mucosal Immunity

Publications & Resources

Relevant Project Investigator Publications:


David Artis and E. John Wherry

Sonnenberg GF, Monticelli LA, Alenghat T, Fung TC, Hutnick NA, Kunisawa J, Shibata N, Grunberg S, Sinha R, Zahm AM, Tardif MR, Sathaliyawala T, Kubota M, Farber DL, Collman RG, Shaked A, Fouser LA, Weiner DB, Tessier PA, Friedman JR, Kiyono H, Bushman FD, Chang KM, Artis D. Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria. Science. 2012 Jun 8;336(6086):1321-5. doi: 10.1126/science.1222551. Epub 2012 Jun 6.

Tomov VT, Osborne LC, Dolfi DV, Sonnenberg GF, Monticelli LA, Mansfield K, Virgin HW, Artis D, Wherry EJ. Persistent enteric murine norovirus infection is associated with functionally suboptimal virus-specific CD8 T cell responses. J Virol. 2013 Jun;87(12):7015-31. doi: 10.1128/JVI.03389-12. Epub 2013 Apr 17.

Kim BS, Siracusa MC, Saenz SA, Noti M, Monticelli LA, Sonnenberg GF, Hepworth MR, Van Voorhees AS, Comeau MR, Artis D. TSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammation. Sci Transl Med. 2013 Jan 30;5(170):170ra16. doi: 10.1126/scitranslmed.3005374.

Saenz SA, Siracusa MC, Monticelli LA, Ziegler CG, Kim BS, Brestoff JR, Peterson LW, Wherry EJ, Goldrath AW, Bhandoola A, Artis D. IL-25 simultaneously elicits distinct populations of innate lymphoid cells and multi-potent progenitor type 2 (MPPtype2) cells. J Exp Med. 2013 Aug 26;210(9):1823-37. doi: 10.1084/jem.20122332. Epub 2013 Aug 19.

Noti M, Wojno ED, Kim BS, Siracusa MC, Giacomin PR, Nair MG, Benitez AJ, Ruymann KR, Muir AB, Hill DA, Chikwava KR, Moghaddam AE, Sattentau QJ, Alex A, Zhou C, Yearley JH, Menard-Katcher P, Kubo M, Obata-Ninomiya K, Karasuyama H, Comeau MR, Brown-Whitehorn T, de Waal Malefyt R, Sleiman PM, Hakonarson H, Cianferoni A, Falk GW, Wang ML, Spergel JM, Artis D. Thymic stromal lymphopoietin-elicited basophil responses promote eosinophilic esophagitis. Nat Med. 2013 Aug;19(8):1005-13. doi: 10.1038/nm.3281. Epub 2013 Jul 21.

Alenghat T, Osborne LC, Saenz SA, Kobuley D, Ziegler CG, Mullican SE, Choi I, Grunberg S, Sinha R, Wynosky-Dolfi M, Snyder A, Giacomin PR, Joyce KL, Hoang TB, Bewtra M, Brodsky IE, Sonnenberg GF, Bushman FD, Won KJ, Lazar MA, Artis D. Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis. Nature. 2013 Dec 5;504(7478):153-7. doi: 10.1038/nature12687. Epub 2013 Nov 3.

Siracusa MC, Saenz SA, Wojno ED, Kim BS, Osborne LC, Ziegler CG, Benitez AJ, Ruymann KR, Farber DL, Sleiman PM, Hakonarson H, Cianferoni A, Wang ML, Spergel JM, Comeau MR, Artis D. Thymic stromal lymphopoietin-mediated extramedullary hematopoiesis promotes allergic inflammation. Immunity. 2013 Dec 12;39(6):1158-70. doi: 10.1016/j.immuni.2013.09.016.

Sonnenberg GF, Monticelli LA, Elloso MM, Fouser LA, Artis D (2011) CD4(+) lymphoid tissue-inducer cells promote innate immunity in the gut. Immunity. 34(1):122-34. PMID: 21194981

Siracusa MC, Saenz SA, Hill DA, Kim BS, Headley MB, Doering TA, Wherry JE, Jessup HK, Siegel LA, Kambayashi T, Dudek EC, Kubo M, Cianferoni A, Spergel JM, Ziegler SF, Comeau MR and Artis, D (2011).  TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation.  Nature doi: 10.1038 /nature10329

Monticelli, LA, Sonnenberg, GF, Abt, MC, Alenghat, T, Ziegler, CGK, Doering, TA, Angelosanto, JM, Laidlaw, BJ, Yang, CY, Sathaliyawala, T, Kubota, M, Turner, D, Diamond, JM, Goldrath, AW, Farber, DL, Collman, RG, Wherry, EJ, Artis, D (2011). Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus. Nat Immunol doi: 10.1038.ni.2131

Blackburn, S.D., Shin, H., Haining, W.N., Zou, T., Workman, C.J., Polley, A., Betts, M.R., Freeman, G.J., Vignali, D.A.A., Wherry, E.J. Co-regulation of CD8 T cell exhaustion during chronic viral infection by multiple inhibitory receptors.  Nat. Immunol. 10:29-37. PMID: 19043418



Xian-Ming Chen

MicroRNA regulation of innate immune responses in epithelial cells.Zhou R, O'Hara SP, Chen XM. Cell Mol Immunol. 2011 Sep;8(5):371-9. doi: 10.1038/cmi.2011.19. Epub 2011 Jul 4. PMID: 21725335

NF-kappaB p65-dependent transactivation of miRNA genes following Cryptosporidium parvum infection stimulates epithelial cell immune responses. Zhou R, Hu G, Liu J, Gong AY, Drescher KM, Chen XM. PLoS Pathog. 2009 Dec;5(12):e1000681. Epub 2009 Dec 4. PMID:  19997496 Free PMC Article



Marco Colonna & Scott Hultgren

Early severe inflammatory responses to uropathogenic E. coli predispose to chronic and recurrent urinary tract infection. Hannan TJ, Mysorekar IU, Hung CS, Isaacson-Schmid ML, Hultgren SJ. PLoS Pathog. 2010 Aug 12; 6(8): e1001042.

Enterococcus faecalis overcomes foreign body-mediated inflammation to establish urinary tract infections. Guiton PS, Hannan TJ, Ford BA, Caparon MG, Hultgren SJ. Infect Immunity, in press.

AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch. Lee JS, Cella M, McDonald KG, Garlanda C, Kennedy GD, Nukaya M, Mantovani A, Kopan R, Bradfield CA, Newberry RD, Colonna M. Nat Immunol. 2011 Nov 20;13(2):144-51. doi: 10.1038/ni.2187.

A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity. Cella M, Fuchs A, Vermi W, Facchetti F, Otero K, Lennerz JK, Doherty JM, Mills JC, Colonna M. Nature. 2009 Feb 5;457(7230):722-5. Epub 2008 Nov 2.



Gunnar C. Hansson

Johansson, M. E. V., Phillipson, M., Petersson, J., Holm, L., Velcich, A., and Hansson, G. C. The inner of the two Muc2 mucin dependent mucus layers in colon is devoid of bacteria. Proc.Natl.Acad.Sci.USA 105, 15064-15069. 2008. PMID: 21327117 PMCID: PMC3035142 Free PMC Article

Holmén Larsson, J. M., Karlsson, H., Grĺberg Crespo, J., Johansson, M. E. V., Eklund, L., Sjövall, H., and Hansson, G. C. An Altered O-glycosylation Profile of the MUC2 Mucin Occurs in Active Ulcerative Colitis and is Associated with Increased Inflammation. Infl.Bowel Dis. 17, 2299-2307. 2011.

Johansson, M. E. V., Gustafsson, J. K., Sjoberg, K. E., Pettersson, J., Holm, L., Sjovall, H., and Hansson, G. C. Bacteria penetrate the inner mucus layer before inflammation in the Dextran sulfate colitis model. PLoS ONE 5, e12238. 2010. PMID: 20805871 Free PMC Article



David Lewinsohn and Marielle Gold

MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage. Gold MC, McLaren JE, Reistetter JA, Smyk-Pearson S, Ladell K, Swarbrick GM, Yu YY, Hansen TH, Lund O, Nielsen M, Gerritsen B, Kesmir C, Miles JJ, Lewinsohn DA, Price DA, Lewinsohn DM. J Exp Med. 2014 Jul 28;211(8):1601-10. doi: 10.1084/jem.20140507. Epub 2014 Jul 21. PubMed PMID: 25049333; PubMed Central PMCID: PMC4113934.

Low levels of peripheral CD161++CD8+ mucosal associated invariant T (MAIT) cells are found in HIV and HIV/TB co-infection. Wong EB, Akilimali NA, Govender P, Sullivan ZA, Cosgrove C, Pillay M, Lewinsohn DM, Bishai WR, Walker BD, Ndung'u T, Klenerman P, Kasprowicz VO. PLoS One. 2013 Dec 31;8(12):e83474. doi: 10.1371/journal.pone.0083474. eCollection 2013.

Mucosal associated invariant T cells and the immune response to infection. Gold MC, Lewinsohn DM. Microbes Infect. 2011 Aug;13(8-9):742-8. doi: 10.1016/j.micinf.2011.03.007. Epub 2011 Mar 31.

Co-dependents: MR1-restricted MAIT cells and their antimicrobial function. Gold MC, Lewinsohn DM. Nat Rev Microbiol. 2013 Jan;11(1):14-9. doi: 10.1038/nrmicro2918. Epub 2012 Nov 26.

Human mucosal associated invariant T cells detect bacterially infected cells. Gold MC, Cerri S, Smyk-Pearson S, Cansler ME, Vogt TM, Delepine J, Winata E, Swarbrick GM, Chua WJ, Yu YY, Lantz O, Cook MS, Null MD, Jacoby DB, Harriff MJ, Lewinsohn DA, Hansen TH, Lewinsohn DM. PLoS Biol. 2010 Jun 29;8(6):e1000407. PMID:  20613858 Free PMC Article



Miriam Merad and Anna Karolina Palucka

Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis. Mortha A, Chudnovskiy A, Hashimoto D, Bogunovic M, Spencer SP, Belkaid Y, Merad M.. Science. 2014 Mar 28;343(6178):1249288. doi: 10.1126/science.1249288. Epub 2014 Mar 13.

Dendritic cell and macrophage heterogeneity in vivo. Hashimoto D, Miller J, Merad M. Immunity. 2011 Sep 23;35(3):323-35. Immunity. 2011 Sep 23;35(3):323-35.

Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine. Lewis KL, Caton ML, Bogunovic M, Greter M, Grajkowska LT, Ng D, Klinakis A, Charo IF, Jung S, Gommerman JL, Ivanov II, Liu K, Merad M, Reizis B. Immunity. 2011 Nov 23;35(5):780-91. Epub 2011 Oct 20.

The origin and development of nonlymphoid tissue CD103+ DCs. Ginhoux F, Liu K, Helft J, Bogunovic M, Greter M, Hashimoto D, Price J, Yin N, Bromberg J, Lira SA, Stanley ER, Nussenzweig M, Merad M. J Exp Med. 2009 Dec 21;206(13):3115-30. Epub 2009 Dec 14. Free PMC Article

Origin of the lamina propria dendritic cell network. Bogunovic M, Ginhoux F, Helft J, Shang L, Hashimoto D, Greter M, Liu K, Jakubzick C, Ingersoll MA, Leboeuf M, Stanley ER, Nussenzweig M, Lira SA, Randolph GJ, Merad M. Immunity. 2009 Sep 18;31(3):513-25. Epub 2009 Sep 10.



Eyal Raz

Cyclic AMP concentrations in dendritic cells induce and regulate Th2 immunity and allergic asthma. Lee J, Kim TH, Murray F, Li X, Choi SS, Broide DH, Corr M, Lee J, Webster NJ, Insel PA, Raz E. Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1529-34. doi: 10.1073/pnas.1417972112. Epub 2015 Jan 20. PubMed PMID: 25605931.

The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4+ T cells. Bertin S, Aoki-Nonaka Y, de Jong PR, Nohara LL, Xu H, Stanwood SR, Srikanth S, Lee J, To K, Abramson L, Yu T, Han T, Touma R, Li X, González-Navajas JM, Herdman S, Corr M, Fu G, Dong H, Gwack Y, Franco A, Jefferies WA, Raz E. Nat Immunol. 2014 Nov;15(11):1055-63. doi: 10.1038/ni.3009. Epub 2014 Oct 5. PubMed PMID: 25282159.

Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis. de Jong PR, Takahashi N, Harris AR, Lee J, Bertin S, Jeffries J, Jung M, Duong J, Triano AI, Lee J, Niv Y, Herdman DS, Taniguchi K, Kim CW, Dong H, Eckmann L, Stanford SM, Bottini N, Corr M, Raz E. J Clin Invest. 2014 Sep 2;124(9):3793-806. doi: 10.1172/JCI72340. Epub 2014 Aug 1. PubMed PMID: 25083990; PubMed Central PMCID: PMC4151223.

TRPM8 on mucosal sensory nerves regulates colitogenic responses by innate immune cells via CGRP. de Jong PR, Takahashi N, Peiris M, Bertin S, Lee J, Gareau MG, Paniagua A, Harris AR, Herdman DS, Corr M, Blackshaw LA, Raz E. Mucosal Immunol. 2014 Oct 1. doi: 10.1038/mi.2014.82. [Epub ahead of print] PubMed PMID: 25269705.

Divergent requirement for Gαs and cAMP in the differentiation and inflammatory profile of distinct mouse Th subsets. Li X, Murray F, Koide N, Goldstone J, Dann SM, Chen J, Bertin S, Fu G, Weinstein LS, Chen M, Corr M, Eckmann L, Insel PA, Raz E. Journal of Clinical Investigation. Vol. 122. No. 3. March 2012. pp 963-73. PubMed. Full Text.

Type I interferons maintain foxp3 expression and T-regulatory cell functions under inflammatory conditions in mice. Lee SE, Li X, Kim JC, Lee J, González-Navajas JM, Hong SH, Park IK, Rhee JH, Raz E. Gastroenterology. 2012 Jul;143(1):145-54. Epub 2012 Apr 1. PubMed. Full Text.

Mucosal adjuvant activity of cholera toxin requires Th17 cells and protects against inhalation anthrax. Datta SK, Sabet M, Nguyen KP, Valdez PA, Gonzalez-Navajas JM, Islam S, Mihajlov I, Fierer J, Insel PA, Webster NJ, Guiney DG, Raz E.  20479237 Free PMC Article

Divergent role of G?s in CD4 T cells on Th subset differentiation and their inflammatory profile. Xiangli Li1, Fiona Murray1,2, Naoki Koide1, Jonathan Goldstone1, Jianzhong Chen1, Samuel Bertin1, Guo Fu3, Lee S. Weinstein4, Min Chen4, Maripat Corr1, Lars Eckmann1, Paul A. Insel1,2, and Eyal Raz1*


Mucosal Immunology Studies Team (MIST) - Improving Understanding of Mucosal Immunity