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David Artis and Gregory Sonnenberg

Zhou L, Sonnenberg GF. Essential immunologic orchestrators of intestinal homeostasis. Sci Immunol. 2018 Feb 9;3(20):eaao1605. doi: 10.1126/sciimmunol.aao1605. PubMed PMID: 26878233.

Klose CSN, Mahlakõiv T, Moeller JB, Rankin LC, Flamar AL, Kabata H, Monticelli LA, Moriyama S, Putzel GG, Rakhilin N, Shen X, Kostenis E, König GM, Senda T, Carpenter D, Farber DL, Artis D. The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation. Nature. 2017 Sep 14;549(7671):282-286. doi: 10.1038/nature23676. Epub 2017 Sep 6. PubMed PMID: 28869965.

Monticelli LA, Buck MD, Flamar AL, Saenz SA, Tait Wojno ED, Yudanin NA, Osborne LC, Hepworth MR, Tran SV, Rodewald HR, Shah H, Cross JR, Diamond JM, Cantu E, Christie JD, Pearce EL, Artis D. Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation. Nat Immunol. 2016 Jun;17(6):656-65. doi: 10.1038/ni.3421. Epub 2016 Apr 4. PubMed PMID: 27043409; PubMed Central PMCID: PMC4873382.

Withers DR, Hepworth MR, Wang X, Mackley EC, Halford EE, Dutton EE, Marriott CL, Brucklacher-Waldert V, Veldhoen M, Kelsen J, Baldassano RN, Sonnenberg GF. Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing TH17 cells and preserving group 3 innate lymphoid cells. Nat Med. 2016 Mar;22(3):319-23. doi: 10.1038/nm.4046. Epub 2016 Feb 15. PubMed PMID: 26878233; PubMed Central PMCID: PMC4948756.

Hepworth MR, Fung TC, Masur SH, Kelsen JR, McConnell FM, Dubrot J, Withers DR, Hugues S, Farrar MA, Reith W, Eberl G, Baldassano RN, Laufer TM, Elson CO, Sonnenberg GF. Immune tolerance. Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4⁺ T cells. Science. 2015 May 29;348(6238):1031-5. doi: 10.1126/science.aaa4812. Epub 2015 Apr 23. PubMed PMID: 25908663; PubMed Central PMCID: PMC4449822.


Albert Bendelac

Bunker JJ, Erickson SA, Flynn TM, Henry C, Koval JC, Meisel M, Jabri B, Antonopoulos DA, Wilson PC, Bendelac A. Natural polyreactive IgA antibodies coat the intestinal microbiota. Science. 2017 Oct 20;358(6361). pii: eaan6619. doi: 10.1126/science.aan6619. Epub 2017 Sep 28. PubMed PMID: 28971969.

Bunker JJ, Flynn TM, Koval JC, Shaw DG, Meisel M, McDonald BD, Ishizuka IE, Dent AL, Wilson PC, Jabri B, Antonopoulos DA, Bendelac A. Innate and Adaptive Humoral Responses Coat Distinct Commensal Bacteria with Immunoglobulin A. Immunity. 2015 Sep 15;43(3):541-53. doi: 10.1016/j.immuni.2015.08.007. Epub 2015 Aug 25. PubMed PMID: 26320660; PubMed Central PMCID: PMC4575282.

Constantinides MG, McDonald BD, Verhoef PA, Bendelac A. A committed precursor to innate lymphoid cells. Nature. 2014 Apr 17;508(7496):397-401. doi: 10.1038/nature13047. Epub 2014 Feb 9. PubMed PMID: 24509713; PubMed Central PMCID: PMC4003507.

McDonald BD, Bunker JJ, Ishizuka IE, Jabri B, Bendelac A. Elevated T cell receptor signaling identifies a thymic precursor to the TCRαβ(+)CD4(-)CD8β(-) intraepithelial lymphocyte lineage. Immunity. 2014 Aug 21;41(2):219-29. doi: 10.1016/j.immuni.2014.07.008. Epub 2014 Aug 14. PubMed PMID: 25131532; PubMed Central PMCID: PMC4188477.


Chuck Bevins

Chairatana P, Chu H, Castillo PA, Shen B, Bevins CL, Nolan EM. Proteolysis Triggers Self-Assembly and Unmasks Innate Immune Function of a Human α-Defensin Peptide. Chem Sci. 2016 Mar 1;7(3):1738-1752. doi: 10.1039/C5SC04194E. Epub 2015 Dec 10. PubMed PMID: 27076903; PubMed Central PMCID: PMC4827351.

Clevers HC, Bevins CL. Paneth cells: maestros of the small intestinal crypts.  Annu Rev Physiol. 2013;75: 289-311. doi: 10.1146/annurev-physiol-030212-183744. Review. PubMed PMID: 23398152.

Chu H, Pazgier M, Jung G, Nuccio SP, Castillo PA, de Jong MF, Winter MG, Winter SE, Wehkamp J, Shen B, Salzman NH, Underwood MA, Tsolis RM, Young GM, Lu W, Lehrer RI, Bäumler AJ, Bevins CL. Human α-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets. Science. 2012 Jul 27;337(6093):477-81. doi: 10.1126/science.1218831. Epub 2012 Jun 21. PubMed PMID: 22722251; PubMed Central PMCID: PMC4332406.

Wehkamp J, Salzman NH, Porter E, Nuding S, Weichenthal M, Petras RE, Shen B, Schaeffeler E, Schwab M, Linzmeier R, Feathers RW, Chu H, Lima H Jr, Fellermann K, Ganz T, Stange EF, Bevins CL. Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18129-34. Epub 2005 Dec 5. PubMed PMID: 16330776; PubMed Central PMCID: PMC1306791.


Hilde Cheroutre

Larange A, Cheroutre H. Retinoic Acid and Retinoic Acid Receptors as Pleiotropic Modulators of the Immune System. Annu Rev Immunol. 2016 May 20;34: 369-94. doi: 10.1146/annurev-immunol-041015-055427. Review. PubMed PMID: 27168242.

Vicente-Suarez I, Larange A, Reardon C, Matho M, Feau S, Chodaczek G, Park Y, Obata Y, Gold R, Wang-Zhu Y, Lena C, Zajonc DM, Schoenberger SP, Kronenberg M, Cheroutre H. Unique lamina propria stromal cells imprint the functional phenotype of mucosal dendritic cells. Mucosal Immunol. 2015 Jan;8(1):141-51. doi: 10.1038/mi.2014.51. Epub 2014 Jun 18. PubMed PMID: 24938743; PubMed Central PMCID: PMC4268120.

Cheroutre H, Husain MM. CD4 CTL: living up to the challenge. Semin Immunol. 2013 Nov 15;25(4):273-81. doi: 10.1016/j.smim.2013.10.022. Epub 2013 Nov 15. Review. PubMed PMID: 24246226; PubMed Central PMCID: PMC3886800.

Mucida D, Husain MM, Muroi S, van Wijk F, Shinnakasu R, Naoe Y, Reis BS, Huang Y, Lambolez F, Docherty M, Attinger A, Shui JW, Kim G, Lena CJ, Sakaguchi S, Miyamoto C, Wang P, Atarashi K, Park Y, Nakayama T, Honda K, Ellmeier W, Kronenberg M, Taniuchi I, Cheroutre H. Transcriptional reprogramming of mature CD4⁺ helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes. Nat Immunol. 2013 Mar;14(3):281-9. doi: 10.1038/ni.2523. Epub 2013 Jan 20. PubMed PMID: 23334788; PubMed Central PMCID: PMC3581083.


Marco Colonna & Scott Hultgren

Cervantes-Barragan L, Chai JN, Tianero MD, Di Luccia B, Ahern PP, Merriman J, Cortez VS, Caparon MG, Donia MS, Gilfillan S, Cella M, Gordon JI, Hsieh CS, Colonna M. Lactobacillus reuteri induces gut intraepithelial CD4(+)CD8αα(+) T cells. Science. 2017 Aug 25;357(6353):806-810. doi: 10.1126/science.aah5825. Epub 2017 Aug 3. PubMed PMID: 28775213.

O'Brien VP, Hannan TJ, Yu L, Livny J, Roberson ED, Schwartz DJ, Souza S, Mendelsohn CL, Colonna M, Lewis AL, Hultgren SJ. A mucosal imprint left by prior Escherichia coli bladder infection sensitizes to recurrent disease. Nat Microbiol. 2016 Oct 31;2: 16196. doi: 10.1038/nmicrobiol.2016.196. PubMed PMID: 27798558; PubMed Central PMCID: PMC5308540.

Nagamatsu K, Hannan TJ, Guest RL, Kostakioti M, Hadjifrangiskou M, Binkley J, Dodson K, Raivio TL, Hultgren SJ. Dysregulation of Escherichia coli α-hemolysin expression alters the course of acute and persistent urinary tract infection. Proc Natl Acad Sci U S A. 2015 Feb 24;112(8): E871-80. doi: 10.1073/pnas.1500374112. Epub 2015 Feb 9. PubMed PMID: 25675528; PubMed Central PMCID: PMC4345586.

Hannan TJ, Roberts PL, Riehl TE, van der Post S, Binkley JM, Schwartz DJ, Miyoshi H, Mack M, Schwendener RA, Hooton TM, Stappenbeck TS, Hansson GC, Stenson WF, Colonna M, Stapleton AE, Hultgren SJ. Inhibition of Cyclooxygenase-2 Prevents Chronic and Recurrent Cystitis. EBioMedicine. 2014 Oct 24;1(1):46-57. doi: 10.1016/j.ebiom.2014.10.011. eCollection 2014 Nov. PubMed PMID: 26125048; PubMed Central PMCID: PMC4457352.


Gunnar C. Hansson & Malin E. Johansson

Schroeder BO, Birchenough GMH, Ståhlman M, Arike L, Johansson MEV, Hansson GC, Bäckhed F. Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus Deterioration. Cell Host Microbe. 2018 Jan 10;23(1):27-40. doi: 10.1016/j.chom.2017.11.004. PMID: 29276171.

Wichert R, Ermund A, Schmidt S, Schweinlin M, Ksiazek M, Arnold P, Knittler K, Wilkens F, Potempa B, Rabe B, Stirnberg M, Lucius R, Bartsch JW, Nikolaus S, Falk-Paulsen M, Rosenstiel P, Metzger M, Rose-John S, Potempa J, Hansson GC, Dempsey PJ, Becker-Pauly C. Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB. Cell Rep. 2017 Nov 21;21(8):2090-2103. doi: 10.1016/j.celrep.2017.10.087. PMID: 29166602.

Bergström JH, Birchenough GM, Katona G, Schroeder BO, Schütte A, Ermund A, Johansson ME, Hansson GC. Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein ZG16. Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):13833-13838. Epub 2016 Nov 14. doi: 10.1073/pnas.1611400113. PubMed PMID: 27849619; PubMed Central PMCID: PMC5137749.

Johansson ME, Hansson GC. Immunological aspects of intestinal mucus and mucins. Nat Rev Immunol. 2016 Oct;16(10):639-49. doi: 10.1038/nri.2016.88. Epub 2016 Aug 8. Review. PubMed PMID: 27498766.

Birchenough GM, Nyström EE, Johansson ME, Hansson GC. A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion. Science. 2016 Jun 24;352(6293):1535-42. doi: 10.1126/science.aaf7419. PubMed PMID: 27339979; PubMed Central PMCID: PMC5148821.


De'Broski Herbert

Nieves W, Hung LY, Oniskey TK, Boon L, Foretz M, Viollet B, Herbert DR. Myeloid-Restricted AMPKα1 Promotes Host Immunity and Protects against IL-12/23p40-Dependent Lung Injury during Hookworm Infection. J Immunol. 2016 Jun 1;196(11):4632-40. doi: 10.4049/jimmunol.1502218. Epub 2016 Apr 20. PubMed PMID:  27183598; PubMed Central PMCID: PMC4875814.

Hung LY, Lewkowich IP, Dawson LA, Downey J, Yang Y, Smith DE, Herbert DR. IL-33 drives biphasic IL-13 production for noncanonical Type 2 immunity against hookworms. Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):282-7. doi: 10.1073/pnas.1206587110. Epub 2012 Dec 17. PubMed PMID: 23248269; PubMed Central PMCID: PMC3538196.

Wills-Karp M, Rani R, Dienger K, Lewkowich I, Fox JG, Perkins C, Lewis L, Finkelman FD, Smith DE, Bryce PJ, Kurt-Jones EA, Wang TC, Sivaprasad U, Hershey GK, Herbert DR. Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection. J Exp Med. 2012 Mar 12;209(3):607-22. doi: 10.1084/jem.20110079. Epub 2012 Feb 13. PubMed PMID: 22329990; PubMed Central PMCID: PMC3302229.


Mitchell Kronenberg

Sibilano R, Gaudenzio N, DeGorter MK, Reber LL, Hernandez JD, Starkl PM, Zurek OW, Tsai M, Zahner S, Montgomery SB, Roers A, Kronenberg M, Yu M, Galli SJ. A TNFRSF14-FcɛRI-mast cell pathway contributes to development of multiple features of asthma pathology in mice. Nat Commun. 2016 Dec 16;7: 13696. doi: 10.1038/ncomms13696. PubMed PMID: 27982078; PubMed Central PMCID: PMC5171877.

Krause P, Zahner SP, Kim G, Shaikh RB, Steinberg MW, Kronenberg M. The tumor necrosis factor family member TNFSF14 (LIGHT) is required for resolution of intestinal inflammation in mice. Gastroenterology. 2014 Jun;146(7):1752-62.e4. doi: 10.1053/j.gastro.2014.02.010. Epub 2014 Feb 19. PubMed PMID: 24560868; PubMed Central PMCID: PMC4035425.

Steinberg MW, Huang Y, Wang-Zhu Y, Ware CF, Cheroutre H, Kronenberg M. BTLA interaction with HVEM expressed on CD8(+) T cells promotes survival and memory generation in response to a bacterial infection. PLoS One. 2013 Oct 30;8(10): e77992. doi: 10.1371/journal.pone.0077992. eCollection 2013. PubMed PMID: 24205057; PubMed Central PMCID: PMC3813523.

Shui JW, Larange A, Kim G, Vela JL, Zahner S, Cheroutre H, Kronenberg M. HVEM signaling at mucosal barriers provides host defence against pathogenic bacteria. Nature. 2012 Aug 9;488(7410):222-5. doi: 10.1038/nature11242. PubMed PMID: 22801499; PubMed Central PMCID: PMC3477500.

Steinberg MW, Turovskaya O, Shaikh RB, Kim G, McCole DF, Pfeffer K, Murphy KM, Ware CF, Kronenberg M. A crucial role for HVEM and BTLA in preventing intestinal inflammation. J Exp Med. 2008 Jun 9;205(6):1463-76. doi: 10.1084/jem.20071160. Epub 2008 Jun 2. PubMed PMID: 18519647; PubMed Central PMCID: PMC2413041.


Bei Liu

Hua Y, Yang Y, Sun S, Iwanowycz S, Westwater C, Reizis B, Li Z, Liu B.Gut homeostasis and regulatory T cell induction depend on molecular chaperone gp96 in CD11c(+) cells. Sci Rep. 2017 May 19;7(1):2171. doi: 10.1038/s41598-017-02415-7.  PubMed PMID: 28526855; PubMed Central PMCID: PMC5438351. 

Yang Y, Torchinsky MB, Gobert M, Xiong H, Xu M, Linehan JL, Alonzo F, Ng C, Chen A, Lin X, Sczesnak A, Liao JJ, Torres VJ, Jenkins MK, Lafaille JJ, Littman DR. Focused specificity of intestinal TH17 cells towards commensal bacterial antigens. Nature. 2014 Jun 5;510(7503):152-6. doi: 10.1038/nature13279. Epub 2014 Apr 13. PubMed PMID: 24739972; PubMed Central PMCID: PMC4128479.

Morales C, Rachidi S, Hong F, Sun S, Ouyang X, Wallace C, Zhang Y, Garret-Mayer E, Wu J, Liu B, Li Z. Immune chaperone gp96 drives the contributions of macrophages to inflammatory colon tumorigenesis. Cancer Res. 2014 Jan 15;74(2):446-59. doi: 10.1158/0008-5472.CAN-13-1677. Epub 2013 Dec 9. PubMed PMID: 24322981; PubMed Central PMCID: PMC4002507.


Eyal Raz

de Jong PR, Taniguchi K, Harris AR, Bertin S, Takahashi N, Duong J, Campos AD, Powis G, Corr M, Karin M, Raz E.ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation. Nat Commun. 2016 May 17;7: 11551. doi: 10.1038/ncomms11551. PubMed PMID: 27187615; PubMed Central PMCID: PMC4873670.

Bertin S, Aoki-Nonaka Y, de Jong PR, Nohara LL, Xu H, Stanwood SR, Srikanth S, Lee J, To K, Abramson L, Yu T, Han T, Touma R, Li X, González-Navajas JM, Herdman S, Corr M, Fu G, Dong H, Gwack Y, Franco A, Jefferies WA, Raz E.The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4⁺ T cells. Nat Immunol. 2014 Nov;15(11):1055-1063. doi: 10.1038/ni.3009. Epub 2014 Oct 5. PubMed PMID: 25282159; PubMed Central PMCID: PMC4843825.

de Jong PR, Takahashi N, Peiris M, Bertin S, Lee J, Gareau MG, Paniagua A, Harris AR, Herdman DS, Corr M, Blackshaw LA, Raz E.TRPM8 on mucosal sensory nerves regulates colitogenic responses by innate immune cells via CGRP. Mucosal Immunol. 2015 May;8(3):491-504. doi: 10.1038/mi.2014.82. Epub 2014 Oct 1. PubMed PMID: 25269705; PubMed Central PMCID: PMC4382463.

de Jong PR, Takahashi N, Harris AR, Lee J, Bertin S, Jeffries J, Jung M, Duong J, Triano AI, Lee J, Niv Y, Herdman DS, Taniguchi K, Kim CW, Dong H, Eckmann L, Stanford SM, Bottini N, Corr M, Raz E.Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis. J Clin Invest. 2014 Sep;124(9):3793-806. doi: 10.1172/JCI72340. Epub 2014 Aug 1. PubMed PMID: 25083990; PubMed Central PMCID: PMC4151223.


Michael Shiloh

Shin HJ, Franco LH, Nair VR, Collins AC, Shiloh MU. A baculovirus-conjugated mimotope vaccine targeting Mycobacterium tuberculosis lipoarabinomannan. PLoS One. 2017 Oct 5;12(10): e0185945. doi: 10.1371/journal.pone.0185945. eCollection 2017. PubMed PMID: 28982200; PubMed Central PMCID: PMC5628901.

Franco LH, Nair VR, Scharn CR, Xavier RJ, Torrealba JR, Shiloh MU, Levine B. The Ubiquitin Ligase Smurf1 Functions in Selective Autophagy of Mycobacterium tuberculosis and Anti-tuberculous Host Defense. Cell Host Microbe. 2017 Sep 13;22(3):421-423. doi: 10.1016/j.chom.2017.08.005. PubMed PMID: 28910640.

Shiloh MU. Mechanisms of mycobacterial transmission: how does Mycobacterium tuberculosis enter and escape from the human host. Future Microbiol. 2016 Dec;11: 1503-1506. Epub 2016 Nov 10. PubMed PMID: 27831741; PubMed Central PMCID:  PMC5549661.

Nair VR, Franco LH, Zacharia VM, Khan HS, Stamm CE, You W, Marciano DK, Yagita H, Levine B, Shiloh MU. Microfold Cells Actively Translocate Mycobacterium tuberculosis to Initiate Infection. Cell Rep. 2016 Aug 2;16(5):1253-1258. doi: 10.1016/j.celrep.2016.06.080. Epub 2016 Jul 21. PubMed PMID: 27452467; PubMed Central PMCID: PMC4972672.


Photo: Immunofluorescence photomicrograph demonstrating the intestinal niche of Nippostrongylus brasiliensis, a hookworm that colonizes the mouse gut and is used to model gastrointestinal nematode infections in humans. Photo Credit: Herbert laboratory, University of Pennsylvania School of Veterinary Medicine.