Publications
View All Publications (2020 - present)
David Artis, PhD
Arifuzzaman M, Collins N, Guo CJ, Artis D. Nutritional regulation of microbiota-derived metabolites: Implications for immunity and inflammation. Immunity. 2024 Jan 9;57(1):14-27. doi: 10.1016/j.immuni.2023.12.009.PMID: 38198849 Review.
Arifuzzaman M, Won TH, Yano H, Uddin J, Emanuel ER, Hu E, Zhang W, Li TT, Jin WB, Grier A, Kashyap S; JRI Live Cell Bank; Guo CJ, Schroeder FC, Artis D. Dietary fiber is a critical determinant of pathologic ILC2 responses and intestinal inflammation. J Exp Med. 2024 May 6;221(5):e20232148. doi: 10.1084/jem.20232148. Epub 2024 Mar 20.PMID: 38506708
Emanuel E, Arifuzzaman M, Artis D. Epithelial-neuronal-immune cell interactions: Implications for immunity, inflammation, and tissue homeostasis at mucosal sites. J Allergy Clin Immunol. 2024 May;153(5):1169-1180. doi: 10.1016/j.jaci.2024.02.004. Epub 2024 Feb 16.PMID: 38369030 Review.
Arifuzzaman M, Won TH, Li TT, Yano H, Digumarthi S, Heras AF, Zhang W, Parkhurst CN, Kashyap S, Jin WB, Putzel GG, Tsou AM, Chu C, Wei Q, Grier A; JRI IBD Live Cell Bank Consortium; Worgall S, Guo CJ, Schroeder FC, Artis D. Inulin fibre promotes microbiota-derived bile acids and type 2 inflammation. Nature. 2022 Nov;611(7936):578-584. doi: 10.1038/s41586-022-05380-y. Epub 2022 Nov 2.PMID: 36323778
Zhang W, Lyu M, Bessman NJ, Xie Z, Arifuzzaman M, Yano H, Parkhurst CN, Chu C, Zhou L, Putzel GG, Li TT, Jin WB, Zhou J; JRI Live Cell Bank; Hu H, Tsou AM, Guo CJ, Artis D. Gut-innervating nociceptors regulate the intestinal microbiota to promote tissue protection. Cell. 2022 Oct 27;185(22):4170-4189.e20. doi: 10.1016/j.cell.2022.09.008. Epub 2022 Oct 14.PMID: 36240781
Tamari M, Del Bel KL, Ver Heul AM, Zamidar L, Orimo K, Hoshi M, Trier AM, Yano H, Yang TL, Biggs CM, Motomura K, Shibuya R, Yu CD, Xie Z, Iriki H, Wang Z, Auyeung K, Damle G, Demircioglu D, Gregory JK, Hasson D, Dai J, Chang RB, Morita H, Matsumoto K, Jain S, Van Dyken S, Milner JD, Bogunovic D, Hu H, Artis D, Turvey SE, Kim BS. Sensory neurons promote immune homeostasis in the lung. Cell. 2024 Jan 4;187(1):44-61.e17. doi: 10.1016/j.cell.2023.11.027. Epub 2023 Dec 21.PMID: 38134932
Kim B, Rothenberg ME, Sun X, Bachert C, Artis D, Zaheer R, Deniz Y, Rowe P, Cyr S. Neuroimmune interplay during type 2 inflammation: Symptoms, mechanisms, and therapeutic targets in atopic diseases. J Allergy Clin Immunol. 2024 Apr;153(4):879-893. doi: 10.1016/j.jaci.2023.08.017. Epub 2023 Aug 25.PMID: 37634890
Wheeler MA, Clark IC, Lee HG, Li Z, Linnerbauer M, Rone JM, Blain M, Akl CF, Piester G, Giovannoni F, Charabati M, Lee JH, Kye YC, Choi J, Sanmarco LM, Srun L, Chung EN, Flausino LE, Andersen BM, Rothhammer V, Yano H, Illouz T, Zandee SEJ, Daniel C, Artis D, Prinz M, Abate AR, Kuchroo VK, Antel JP, Prat A, Quintana FJ. Droplet-based forward genetic screening of astrocyte-microglia cross-talk. Science. 2023 Mar 10;379(6636):1023-1030. doi: 10.1126/science.abq4822. Epub 2023 Mar 9.PMID: 36893254
Jarick KJ, Topczewska PM, Jakob MO, Yano H, Arifuzzaman M, Gao X, Boulekou S, Stokic-Trtica V, Leclère PS, Preußer A, Rompe ZA, Stamm A, Tsou AM, Chu C, Heinrich FR, Guerra GM, Durek P, Ivanov A, Beule D, Helfrich S, Duerr CU, Kühl AA, Stehle C, Romagnani C, Mashreghi MF, Diefenbach A, Artis D, Klose CSN. Non-redundant functions of group 2 innate lymphoid cells. Nature. 2022 Nov;611(7937):794-800. doi: 10.1038/s41586-022-05395-5. Epub 2022 Nov 2.PMID: 36323785
Tsou AM, Yano H, Parkhurst CN, Mahlakõiv T, Chu C, Zhang W, He Z, Jarick KJ, Zhong C, Putzel GG, Hatazaki M; JRI IBD Live Cell Bank Consortium; Lorenz IC, Andrew D, Balderes P, Klose CSN, Lira SA, Artis D. Neuropeptide regulation of non-redundant ILC2 responses at barrier surfaces. Nature. 2022 Nov;611(7937):787-793. doi: 10.1038/s41586-022-05297-6. Epub 2022 Nov 2.PMID: 36323781
Jin WB, Li TT, Huo D, Qu S, Li XV, Arifuzzaman M, Lima SF, Shi HQ, Wang A, Putzel GG, Longman RS, Artis D, Guo CJ. Genetic manipulation of gut microbes enables single-gene interrogation in a complex microbiome. Cell. 2022 Feb 3;185(3):547-562.e22. doi: 10.1016/j.cell.2021.12.035. Epub 2022 Jan 19.PMID: 35051369
Yano H, Artis D. Neuronal regulation of innate lymphoid cell responses. Curr Opin Immunol. 2022 Jun;76:102205. doi: 10.1016/j.coi.2022.102205. Epub 2022 May 12.PMID: 35569418 Review.
Topczewska PM, Rompe ZA, Jakob MO, Stamm A, Leclère PS, Preußer A, Duerr CU, Thole LML, Kotsch K, Artis D, Klose CSN. ILC2 require cell-intrinsic ST2 signals to promote type 2 immune responses.Front Immunol. 2023 Mar 31;14:1130933. doi: 10.3389/fimmu.2023.1130933. eCollection 2023.PMID: 37063913
Zaiss DMW, Pearce EJ, Artis D, McKenzie ANJ, Klose CSN. Cooperation of ILC2s and TH2 cells in the expulsion of intestinal helminth parasites. Nat Rev Immunol. 2024 Apr;24(4):294-302. doi: 10.1038/s41577-023-00942-1. Epub 2023 Oct 5.PMID: 37798539 Review.
Irie M, Sasahara K, Artis D, Kabata H. Current overview of the role of neuropeptides in ILC2s and future directions. Allergol Int. 2022 Jul;71(3):294-300. doi: 10.1016/j.alit.2022.03.002. Epub 2022 Mar 30.PMID: 35367135 Free article. Review.
Arifuzzaman M, Won TH, Li TT, Yano H, Digumarthi S, Heras AF, Zhang W, Parkhurst CN, Kashyap S, Jin WB, Putzel GG, Tsou AM, Chu C, Wei Q, Grier A, JRI IBD Live Cell Bank Consortium, Worgall S, Guo CJ, Schroeder FC, Artis D. Inulin fiber promotes microbiota-derived bile acids and type 2 inflammation. Nature 2022 Nov;611(7936):578-584. doi: 10.1038/s41586-022-05380-y. Epub 2022 Nov 2. PMID: 36323778.
Tsou AM, Yano H, Parkhurst CN1, Mahlakõiv T, Chu C, Zhang W, He Z, Jarick KJ, Zhong C, Putzel GG, Hatazaki M, JRI IBD Live Cell Bank Consortium, Lorenz IC, Andrew D, Balderes P, Klose CSN, Lira SA, Artis D. Neuropeptide regulation of non-redundant ILC2 responses at barrier surfaces. Nature 2022 Nov;611(7937):787-793. doi: 10.1038/s41586-022-05297-6. Epub 2022 Nov 2. PMID: 36323781.
Zhang W, Lyu M, Bessman NJ, Xie Z, Arifuzzaman M, Yano H, Parkhurst CN, Chu C, Zhou L, Putzel GG, Li TT, Jin WB, Zhou J, JRI Live Cell Bank, Hu H, Tsou AM, Guo CJ, Artis D. Gut-innervating nociceptors regulate the intestinal microbiota to promote tissue protection. Cell 2022 Oct 27;185(22):4170-4189.e20. doi: 10.1016/j.cell.2022.09.008. Epub 2022 Oct 14. PMID: 36240781.
Chu C, Parkhurst CN, Zhang W, Zhou L, Yano H, Arifuzzaman M, Artis D. The ChAT-acetylcholine pathway promotes group 2 innate lymphoid cell responses and anti-helminth immunity. Sci Immunol. 2021 Mar 5;6(57):eabe3218. doi: 10.1126/sciimmunol.abe3218. PMID: 33674322
Chung H, Parkhurst CN, Magee EM, Phillips D, Habibi E, Chen F, Yeung BZ, Waldman J, Artis D, Regev A. Joint single-cell measurements of nuclear proteins and RNA in vivo. Nat Methods. 2021 Oct;18(10):1204-1212. doi: 10.1038/s41592-021-01278-1. Epub 2021 Oct 4. PMID: 34608310
Kabata H, Flamar AL, Mahlakõiv T, Moriyama S, Rodewald HR, Ziegler SF, Artis D. Targeted deletion of the TSLP receptor reveals cellular mechanisms that promote type 2 airway inflammation. Mucosal Immunol. 2020 Jul;13(4):626-636. doi: 10.1038/s41385-020-0266-x. Epub 2020 Feb 17. PMID: 32066836
Flamar AL, Klose CSN, Moeller JB, Mahlakõiv T, Bessman NJ, Zhang W, Moriyama S, Stokic-Trtica V, Rankin LC, Putzel GG, Rodewald HR, He Z, Chen L, Lira SA, Karsenty G, Artis D. Interleukin-33 Induces the Enzyme Tryptophan Hydroxylase 1 to Promote Inflammatory Group 2 Innate Lymphoid Cell-Mediated Immunity. Immunity. 2020 Apr 14;52(4):606-619.e6. doi: 10.1016/j.immuni.2020.02.009. Epub 2020 Mar 10. PMID: 32160524.
Monticelli LA, Diamond JM, Saenz SA, Tait Wojno ED, Porteous MK, Cantu E, Artis, D, Christie JD. Innate Lymphoid Cell Composition Is Altered in Primary Graft Dysfunction. Am J Respir Crit Care Med. 2020 Jan 1;201(1):63-72. doi: 10.1164/rccm.201906-1113OC. PMID: 31394048
Review Journals
Klose CSN, Artis D. Innate lymphoid cells control signaling circuits to regulate tissue-specific immunity. Cell Res. 2020 Jun; 30(6): 475 -491. Doi: 10.1038/s41422-020-0323-8. Epub 2020 May 6. PMID: 32376911.
Chu C, Artis D, Chiu IM. Neuro-immune Interactions in the Tissues. Immunity. 2020 Mar 17;52(3):464-474. doi: 10.1016/j.immuni.2020.02.017.PMID: 32187517.
De'Broski R. Herbert PhD
The Secretome of Adult Murine Hookworms Is Shaped by Host Expression of STAT6. Ferguson AA, Rossi HL, Herbert DR. Parasite Immunol. 2024 Jul;46(7):e13056. doi: 10.1111/pim.13056.PMID: 39073185
Hookworms dynamically respond to loss of Type 2 immune pressure. Ferguson AA, Inclan-Rico JM, Lu D, Bobardt SD, Hung L, Gouil Q, Baker L, Ritchie ME, Jex AR, Schwarz EM, Rossi HL, Nair MG, Dillman AR, Herbert DR. PLoS Pathog. 2023 Dec 11;19(12):e1011797. doi: 10.1371/journal.ppat.1011797. eCollection 2023 Dec.PMID: 38079450
A Trefoil factor 3-Lingo2 axis restrains proliferative expansion of type-1 T helper cells during GI nematode infection. Ethgen LM, Pastore C, Lin C, Reed DR, Hung LY, Douglas B, Sinker D, Herbert DR, Belle NM.Mucosal Immunol. 2024 Apr;17(2):238-256. doi: 10.1016/j.mucimm.2024.02.003. Epub 2024 Feb 8.PMID: 38336020
Every cell is an immune cell; contributions of non-hematopoietic cells to anti-helminth immunity. Inclan-Rico JM, Rossi HL, Herbert DR. Mucosal Immunol. 2022 May 10. doi: 10.1038/s41385-022-00518-7. Online ahead of print. PMID: 35538230
Trefoil Factor Family: A Troika for Lung Repair and Regeneration. Rossi HL, Ortiz-Carpena JF, Tucker D, Vaughan AE, Mangalmurti NS, Cohen NA, Herbert DR. Am J Respir Cell Mol Biol. 2021 Nov 16. doi: 10.1165/rcmb.2021-0373TR. PMID: 34784491
Neuroimmune regulatory networks of the airway mucosa in allergic inflammatory disease. Jean EE, Good O, Rico JMI, Rossi HL, Herbert DR. J Leukoc Biol. 2021 Apr 15. doi: 10.1002/JLB.3RU0121-023R. Online ahead of print. PMID: 33857344
Tuft cells in the pathogenesis of chronic rhinosinusitis with nasal polyps and asthma. Sell EA, Ortiz-Carpena JF, Herbert DR, Cohen NA. Ann Allergy Asthma Immunol. 2021 Feb;126(2):143-151. doi: 10.1016/j.anai.2020.10.011. Epub 2020 Oct 26. PMID: 33122124
Oncolytic Myxoma virus infects and damages the tegument of the human parasitic flatworm Schistosoma mansoni. Rahman MM, McFadden G, Ruthel G, Herbert DR, Freedman BD, Greenberg RM, Bais S. Exp Parasitol. 2022 May 19;239:108263. doi: 10.1016/j.exppara.2022.108263. Online ahead of print. PMID: 35598646
Schistosoma mansoni infection induces plasmablast and plasma cell death in the bone marrow and accelerates the decline of host vaccine responses. Musaigwa F, Kamdem SD, Mpotje T, Mosala P, Abdel Aziz N, Herbert DR, Brombacher F, Nono JK. PLoS Pathog. 2022 Feb 14;18(2):e1010327. doi: 10.1371/journal.ppat.1010327. eCollection 2022 Feb. PMID: 35157732
Schistosome TRPML channels play a role in neuromuscular activity and tegumental integrity. Bais S, Norwillo A, Ruthel G, Herbert DR, Freedman BD, Greenberg RM. Biochimie. 2022 Jan 3;194:108-117. doi: 10.1016/j.biochi.2021.12.018 PMID: 34990770
Parasitic helminth infections in humans modulate Trefoil Factor levels in a manner dependent on the species of parasite and age of the host. Adewale B, Heintz JR, Pastore CF, Rossi HL, Hung LY, Rahman N, Bethony J, Diemert D, Babatunde JA, Herbert DR. PLoS Negl Trop Dis. 2021 Oct 18;15(10):e0009550. doi: 10.1371/journal.pntd.0009550. eCollection 2021 Oct. PMID: 34662329
Transgenic expression of a T cell epitope in Strongyloides ratti reveals that helminth-specific CD4+ T cells constitute both Th2 and Treg populations. Douglas B, Wei Y, Li X, Ferguson A, Hung LY, Pastore C, Kurtz JR, McLachlan JB, Nolan TJ, Lok J, Herbert DR. PLoS Pathog. 2021 Jul 8;17(7):e1009709. doi: 10.1371/journal.ppat.1009709. eCollection 2021 Jul. PMID: 34237106
LINGO3 regulates mucosal tissue regeneration and promotes TFF2 dependent recovery from colitis. Zullo KM, Douglas B, Maloney NM, Ji Y, Wei Y, Herbine K, Cohen R, Pastore C, Cramer Z, Wang X, Wei W, Somsouk M, Hung LY, Lengner C, Kohanski MH, Cohen NA, Herbert DR. Scand J Gastroenterol. 2021 Jul;56(7):791-805. doi: 10.1080/00365521.2021.1917650. Epub 2021 May 3. PMID: 33941035
Non-hematopoietic IL-4Rα expression contributes to fructose-driven obesity and metabolic sequelae. Damen MSMA, Stankiewicz TE, Park SH, Helsley RN, Chan CC, Moreno-Fernandez ME, Doll JR, Szabo S, Herbert DR, Softic S, Divanovic S. Int J Obes (Lond). 2021 Nov;45(11):2377-2387. doi: 10.1038/s41366-021-00902-6. Epub 2021 Jul 23. PMID: 34302121
Myeloid-derived interleukin-33 limits the severity of dextran sulfate sodium (DSS)-induced colitis. Hung LY, Pastore CF, Douglas B, Herbert DR. Am J Pathol. 2020 Nov 24:S0002-9440(20)30505-8. doi: 10.1016/j.ajpath.2020.11.004. PMID: 33245913
Cellular context of IL-33 expression dictates impact on anti-helminth immunity. Hung LY, Tanaka Y, Herbine K, Pastore C, Singh B, Ferguson A, Vora N, Douglas B, Zullo K, Behrens EM, Li Hui Tan T, Kohanski MA, Bryce P, Lin C, Kambayashi T, Reed DR, Brown BL, Cohen NA, Herbert DR. Sci Immunol. 2020 Nov 13;5(53):eabc6259. doi: 10.1126/sciimmunol.abc6259. PMID: 33188058
Tuft cells in the pathogenesis of chronic rhinosinusitis with nasal polyps and asthma. Sell EA, Ortiz-Carpena JF, Herbert DR, Cohen NA. Ann Allergy Asthma Immunol. 2020 Oct 26:S1081-1206(20)31144-3. doi: 10.1016/j.anai.2020.10.011. PMID: 33122124 Review
R-spondin 2 mediates neutrophil egress into the alveolar space through increased lung permeability. Jackson, S.R., Costa, M.F.D.M., Pastore, C.F., Zhao, G., Weiner, A.I., Adams, S., Palashikar, G., Quansah, K., Hankenson, K., Herbert, DR, Vaughan, A.E. BMC Res Notes. 2020 Feb 4;13(1):54. doi: 10.1186/s13104-020-4930-8. PMID: 32019591
Chyi-Song Hsieh, MD, PhD
Yi J, Miller AT, Archambault AS, Jones AJ, Bradstreet TR, Bandla S, Hsu YS, Edelson BT, Zhou YW, Fremont DH, Egawa T, Singh S, Wu GF, Hsieh CS. Antigen-specific depletion of CD4 T cells by CAR T cells reveals distinct roles of higher and lower affinity TCRs during autoimmunity (2022). Science Immunology, in press.
Russler-Germain EV, Jung J, Miller AT, Young S, Yi J, Wehmeier A, Fox LE, Monte KJ, Chai JN, Kulkarni DH, Funkhouser-Jones LJ, Wilke G, Durai V, Zinselmeyer BH, Czepielewski RS, Greco S, Murphy KM, Newberry RD, Sibley LD, Hsieh CS. Commensal Cryptosporidium colonization drives cDC1-dependent intestinal Th1-mediated homeostasis (2021). Immunity 54(11):2547-2564. PMCID: PMC8716016
Russler-Germain EV, Yi J, Young S, Nutsch K, Wong HS, Ai TL, Chai JN, Durai V, Kaplan DH, Germain RN, Murphy KM, Hsieh CS. Gut Helicobacter Presentation by Multiple Dendritic Cell Subsets Enables Context-Specific Regulatory T Cell Generation (2021). eLife 10:e54792. PMCID: PMC7877908
Hsieh CS, Rengarajan S, Kau A, Tarazona-Meza C, Nicholson A, Checkley W, Romero K, Hansel NN. Altered IgA Response to Gut Bacteria Is Associated with Childhood Asthma in Peru (2021). J Immunol. 207(2):398-407. PMID: 34193598; PMCID: PMC8516662.
Rengarajan S, Knoop KA, Rengarajan A, Chai JN, Grajales-Reyes JG, Samineni VK, Russler-Germain EV, Ranganathan P, Fasano A, Sayuk GS, Gereau IV RW, Kau AL, Knights D, Kashyap PC, Ciorba MA, Newberry RD, Hsieh CS. A potential role for stress-induced microbial alterations in IgA-associated irritable bowel syndrome with diarrhea (2020). Cell Reports Med. 1: 100124. PMCID: PMC7659537
Rengarajan S, Vivio EE, Parkes M, Peterson DA, Roberson EDO, Newberry RD, Ciorba MA, Hsieh CS. Dynamic immunoglobulin responses to gut bacteria during inflammatory bowel disease (2020). Gut Microbes 11:405.
Christopher A. Hunter, Ph.D.
Pardy, R. D. et al. Analysis of intestinal epithelial cell responses to Cryptosporidium highlights the temporal effects of IFN-gamma on parasite restriction. PLoS Pathog 20, e1011820 (2024).
Wallbank, B., Pardy, R. D., Brodsky, I. E., Hunter, C. A. & Striepen, B. Cryptosporidium impacts epithelial turnover and is resistant to induced cell death. mBio in press (2024).
Walzer, K. A. et al. Transcriptional control of the Cryptosporidium life cycle. Nature (2024).
Cohn, I. S., Henrickson, S. E., Striepen, B. & Hunter, C. A. Immunity to Cryptosporidium: Lessons from Acquired and Primary Immunodeficiencies. J Immunol 209, 2261-2268 (2022).
Cohn, I. S. et al. Intestinal cDC1s provide cues required for CD4+ T cell-mediated resistance to Cryptosporidium. J Exp Med 221 (2024).
Haskins, B. E. et al. Dendritic cell-mediated responses to secreted Cryptosporidium effectors promote parasite-specific CD8(+) T cell responses. Mucosal Immunol 17, 387-401 (2024).
Pardy, R. D., Wallbank, B. A., Striepen, B. & Hunter, C. A. Immunity to Cryptosporidium: insights into principles of enteric responses to infection. Nat Rev Immunol 24, 142-155 (2024).
Doke T, Abedini A, Aldridge DL, Yang YW, Park J, Hernandez CM, Balzer MS, Shrestra R, Coppock G, Rico JMI, Han SY, Kim J, Xin S, Piliponsky AM, Angelozzi M, Lefebvre V, Siracusa MC, Hunter CA, Susztak K. 2022. Single-cell analysis identifies the interaction of altered renal tubules with basophils orchestrating kidney fibrosis. Nat Immunol 23: 947-59
Gibson AR, Sateriale A, Dumaine JE, Engiles JB, Pardy RD, Gullicksrud JA, O'Dea KM, Doench JG, Beiting DP, Hunter CA, Striepen B. 2022. A genetic screen identifies a protective type III interferon response to Cryptosporidium that requires TLR3 dependent recognition. PLoS Pathog 18: e1010003
Christian DA, Adams TA, 2nd, Shallberg LA, Phan AT, Smith TE, Abraha M, Perry J, Ruthel G, Clark JT, Pritchard GH, Aronson LR, Gossa S, McGavern DB, Kedl RM, Hunter CA. 2022. cDC1 coordinate innate and adaptive responses in the omentum required for T cell priming and memory. Sci Immunol 7: eabq7432
Shallberg LA, Phan AT, Christian DA, Perry JA, Haskins BE, Beiting DP, Harris TH, Koshy AA, Hunter CA. 2022. Impact of secondary TCR engagement on the heterogeneity of pathogen-specific CD8+ T cell response during acute and chronic toxoplasmosis. PLoS Pathog 18: e1010296
Perry JA, Shallberg L, Clark JT, Gullicksrud JA, DeLong JH, Douglas BB, Hart AP, Lanzar Z, O'Dea K, Konradt C, Park J, Kuchroo JR, Grubaugh D, Zaretsky AG, Brodsky IE, Malefyt RD, Christian DA, Sharpe AH, Hunter CA. 2022. PD-L1-PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection. Nature Immunology 23: 743-+
Clark JT, Christian DA, Gullicksrud JA, Perry JA, Park J, Jacquet M, Tarrant JC, Radaelli E, Silver J, Hunter CA. 2021. IL-33 promotes innate lymphoid cell-dependent IFN-gamma production required for innate immunity to Toxoplasma gondii. Elife 10: doi: 10.7554/eLife.65614
Sateriale A, Gullicksrud JA, Engiles JB, McLeod BI, Kugler EM, Henao-Mejia J, Zhou T, Ring AM, Brodsky IE, Hunter CA, Striepen B. 2021. The intestinal parasite Cryptosporidium is controlled by an enterocyte intrinsic inflammasome that depends on NLRP6. Proc Natl Acad Sci U S A 118
Gullicksrud JA, Sateriale A, Engiles JB, Gibson AR, Shaw S, Hutchins ZA, Martin L, Christian DA, Taylor GA, Yamamoto M, Beiting DP, Striepen B, Hunter CA. 2021. Enterocyte-innate lymphoid cell crosstalk drives early IFN-gamma-mediated control of Cryptosporidium. Mucosal Immunol
Lam LKM, Murphy S, Kokkinaki D, Venosa A, Sherrill-Mix S, Casu C, Rivella S, Weiner A, Park J, Shin S, Vaughan AE, Hahn BH, Odom John AR, Meyer NJ, Hunter CA, Worthen GS, Mangalmurti NS. 2021. DNA binding to TLR9 expressed by red blood cells promotes innate immune activation and anemia. Sci Transl Med 13: eabj1008
Aldridge DL, Phan AT, de Waal Malefyt R, Hunter CA. 2021. Limited Impact of the Inhibitory Receptor TIGIT on NK and T Cell Responses during Toxoplasma gondii Infection. Immunohorizons 5: 384-94
Ivaylo Ivanov, Ph.D.
Araujo LP, Edwards M, Irie K, Huang Y, Kawano Y, Tran A, De Michele S, Bhagat G, Wang HH, Ivanov II. Context-dependent role of group 3 innate lymphoid cells in mucosal protection. Science Immunology 2024, vol 9, In Press.
Brockmann L, Tran A, Huang Y, Edwards M, Ronda C, Wang HH, Ivanov II. Intestinal microbiota-specific Th17 cells possess regulatory properties and suppress effector T cells via c-MAF and IL-10. Immunity 2023, Dec 12;56(12):2719-2735.e7. PMID:38039966
Kawano Y, Edwards M, Huang Y, Bilate AM, Araujo LP, Tanoue T, Atarashi K, Ladinsky MS, Reiner SL, Wang HH, Mucida D, Honda K, Ivanov II. Dietary sugar-induced microbiota imbalance disrupts immune-mediated protection from metabolic syndrome. Cell 2022 Sep 15;185(19):3501-3519.e20. PMID: 36041436.
Ivanov II, Tuganbaev T, Skelly AN, Honda K. T cell responses to the microbiota. Annual Review of Immunology. 2022 Feb 3. PMID: 35113732
Zhang X, Bandyopadhyay S, Araujo LP, Tong K, Flores J, Laubitz D, Zhao Y, Yap G, Wang J, Zou Q, Ferraris R, Zhang L, Hu W, Bonder EM, Kiela PR, Coffey R, Verzi MP, Ivanov II, Gao N. Elevating EGFR-MAPK program by a nonconventional Cdc42 enhances intestinal epithelial survival and regeneration. JCI Insight. 2020 Aug 20;5(16):135923. PMID 32686657
Ladinsky MS, Araujo LP, Zhang X, Veltri J, Galan-Diez M, Soualhi S, Lee C, Irie K, Pinker E, Narushima S, Bandyopadhyay S, Nagayama M, Elhenawy W, Coombes BK, Ferraris RP, Honda K, Iliev ID, Gao N, Bjorkman PJ, Ivanov II. Endocytosis of commensal antigens by intestinal epithelial cells regulates mucosal T cell homeostasis. Science 2019 Mar 9;363(6431). PMID 30846568
Rodney D. Newberry, M.D.
Kulkarni DH, Rusconi B, Floyd AN, Joyce EL, Talati KB, Kousik H, Alleyne D, Harris DL, Garnica L, McDonough R, Bidani SS, Kulkarni HS, Newberry EP, McDonald KG, Newberry RD. Gut microbiota induces weight gain and inflammation in the gut and adipose tissue independent of manipulations in diet, genetics, and immune development. Gut microbes. 2023;15(2):2284240. Epub 20231130. doi: 10.1080/19490976.2023.2284240. PubMed PMID: 38036944; PMCID: PMC10730159.
Schill EM, Joyce EL, Floyd AN, Udayan S, Rusconi B, Gaddipati S, Barrios BE, John V, Kaye ME, Kulkarni DH, Pauta JT, McDonald KG, Newberry RD. Vancomycin-induced gut microbial dysbiosis alters enteric neuron-macrophage interactions during a critical period of postnatal development. Frontiers in immunology. 2023;14:1268909. Epub 20231012. doi: 10.3389/fimmu.2023.1268909. PubMed PMID: 37901245; PMCID: PMC10602895
Rusconi B, Bard AK, McDonough R, Kindsvogel AM, Wang JD, Udayan S, McDonald KG, Newberry RD, Tarr PI. Intergenerational protective anti-gut commensal immunoglobulin G originates in early life. Proc Natl Acad Sci U S A. 2024;121(13):e2309994121. Epub 20240322. doi: 10.1073/pnas.2309994121. PubMed PMID: 38517976; PMCID: PMC10990157.
Udayan S, Stamou P, Crispie F, Hickey A, Floyd AN, Hsieh CS, Cotter PD, O'Sullivan O, Melgar S, O'Toole PW, Newberry RD, Rossini V, Nally K. Identification of Gut Bacteria such as Lactobacillus johnsonii that Disseminate to Systemic Tissues of Wild Type and MyD88-/- Mice. Gut microbes. 2022;14(1):2007743. doi: 10.1080/19490976.2021.2007743. PubMed PMID: 35023810; PMCID: PMC8765072.
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Matthew E. Pipkin, Ph.D.
Diao H, Chen R, Tsuda SM, Wang D, Frederick MA, Kim J, Karunadharma P, Martinez GJ, Getzler AJ, Toma C, Milner JJ, Venables TC, Martin DM, Goldrath AW, Crotty S, Pipkin ME. Single-cell lineage trajectories and chromatin regulators that initialize antiviral CD8 T cell ontogeny. In revision. Available via bioRxiv: https://doi.org/10.1101/2021.08.11.456014
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Gwendalyn J. Randolph, PhD.
Uzzan M, Martin JC, Mesin L, Livanos AE, Castro-Dopico T, Huang R, Petralia F, Magri G, Kumar S, Zhao Q, Rosenstein AK, Tokuyama M, Sharma K, Ungaro R, Kosoy R, Jha D, Fischer J, Singh H, Keir ME, Ramamoorthi N, Gorman WEO, Cohen BL, Rahman A, Cossarini F, Seki A, Leyre L, Vaquero ST, Gurunathan S, Grasset EK, Losic B, Dubinsky M, Greenstein AJ, Gottlieb Z, Legnani P, George J, Irizar H, Stojmirovic A, Brodmerkel C, Kasarkis A, Sands BE, Furtado G, Lira SA, Tuong ZK, Ko HM, Cerutti A, Elson CO, Clatworthy MR, Merad M, Suárez-Fariñas M, Argmann C, Hackney JA, Victora GD, Randolph GJ, Kenigsberg E, Colombel JF, Mehandru S. Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity. Nat Med. 2022 Apr;28(4):766-779. doi: 10.1038/s41591-022-01680-y.
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Han YH, Onufer EJ, Sprung RW, Davidson WS, Czepielewski RS, Wohltmann M, Sorci-Thomas MG, Warner BW, Randolph GJ. 2021. Enterically derived high-density lipoprotein restrains liver injury through the portal vein. Science, 373, 410; DOI: 10.1126/science.abe6729. [Feature articles in Immunity, and Nature Rev Gastro Hepatol]
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Huang LH, Deepak P, Ciorba MA, Mittendorfer B, Patterson BW, Randolph GJ. 2020. Postprandial chylomicron output and transport through intestinal lymphatics are not impaired in active Crohn's disease. Gastroenterology, 159:1955-9156. doi: 10.1053/j.gastro.2020.07.012. [letter to the editor published, along with our reply, April 2021]
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Boris Striepen, PhD
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Gregory F. Sonnenberg, PhD
Ahmed A, Joseph AM, Zhou J, Horn V, Uddin J, Lyu M, Goc J; JRI Live Cell Bank; Sockolow RE, Wing JB, Vivier E, Sakaguchi S, Sonnenberg GF. CTLA-4-expressing ILC3s restrain interleukin-23-mediated inflammation. Nature. 2024 Jun;630(8018):976-983. doi: 10.1038/s41586-024-07537-3. Epub 2024 Jun 12. PMID: 38867048.
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Horn V, Sonnenberg GF. Group 3 innate lymphoid cells in intestinal health and disease. Nat Rev Gastroenterol Hepatol. 2024 Jun;21(6):428-443. doi: 10.1038/s41575-024-00906-3. Epub 2024 Mar 11. PMID: 38467885; PMCID: PMC11144103.
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Mark S. Sundrud, Ph.D.
K Sudo, A Delmas-Eliason, S Soucy, KE Barrack, J Liu, A Balasubramanian, CJ Shu, MJ James, CL Hegner, HD Dionne, A Rodriguez-Palacios, HM Krause, GA O'Toole, SJ Karpen, PA Dawson, D Schultz, MS Sundrud. Quantifying absorption and functions of intestinal bile acid pools in mice. bioRxiv [Preprint]. 2024 Feb 18:2024.02.16.580658. doi: 10.1101/2024.02.16.580658. (In press at CMGH)
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ML Chen, X Huang, H Wang, Y Liu, J Shang, A Eliason, C Hegner, H Park, B Frey, G Wang, DJ Kojetin, CT Weaver, ME Pipkin, DD Moore, MS Sundrud. 2021. CAR directs T cell adaptation to bile acids in the small intestine. Nature. May;593(7857):147-151. doi: 10.1038/s41586-021-03421-6. Epub 2021 Apr 7.
R Wang, S Campbell, M Amir, MA Bassette, A Eliason, MS Sundrud, TM Kamenecka, LA Solt. 2021. Genetic and pharmacological inhibition of the nuclear receptor RORa regulates TH17 driven inflammatory disorders. Nat Comm. Jan 4;12(1):76.
AR Basson, C Chen, F Sagl, A Trotter, I Bederman, A Gomez-Nguyen, MS Sundrud, S Ilic, F Cominelli, A Rodriguez-Palacios. Regulation of Intestinal Inflammation by Dietary Fats. Front Immunol. 2021 Feb 2;11:604989. doi: 10.3389/fimmu.2020.604989. eCollection 2020.
ML Chen, A Sun, W Cao, A Eliason, KM Mendez, AJ Getzler, S Tsuda, H Diao, C Mukori, NE Bruno, SY Kim, ME Pipkin, SB Koralov, MS Sundrud. 2020. Physiologic expression and function of the multidrug transporter MDR1 in cytotoxic T lymphocytes. J Exp Med. May 4;217(5):e20191388.
Y Kim, MS Sundrud, C Zhou, M Edenius, D Zocco, K Powers, EH Noss, MB Brenner, A Rao, R Mazitschek, CY Yeo, M Whitman, TL Keller. 2020. Aminoacyl-tRNA Synthetase Inhibition Activates a Novel Pathway that Branches from the Canonical Amino Acid Response in Mammalian Cells. Proc Natl Acad Sci USA. Apr 21;117(16):8900-8911. #co-first author.
A Basson , A LaSalla , G Lam , D Kulpins , E Moen , MS Sundrud , J Miyoshi , S Ilic , B Theriault , F Cominelli, A. Rodriguez-Palacios. 2020. Understanding 'artificial' mouse-microbiome heterogeneity and six actionable themes to increase study power and reproducibility. Sci Rep. Mar 19;10(1):5039.
Casey T. Weaver, MD
Pham, D., D.J. Silberger, M. Gao, K.N. Nguyen, R.D. Hatton+, and C.T Weaver+. Batf stabilizes the Th17 cell developmental program through impairment of Stat5-dependent recruitment of Ets1-Runx1 complexes. EMBO J (in revision).
Zindl, C.L., S.J. Witte, V.A. Laufer, M. Gao, Z. Yue, Daniel J. Silberger, S.N. Harbour, J.R. Singer, Duy Pham, C.E. Moseley, B. Cai, H. Turner, F.E. Lund, B.A. Vallance, A.F. Rosenberg, J.Y. Chen, R.T. Hatton1 and C.T. Weaver. A non-redundant role for T cell-derived IL-22 in antibacterial defense of colonic crypts. Immunity 55:494-511, 2022.
Kahan. S.M., R.K. Bakshi, J.T. Ingram, R.C. Hendrickson, E.J. Lefkowitz, D.K. Crossman, L.E. Harrington, C.T. Weaver, and A.J. Zajac. Intrinsic IL-2 production by effector CD8 T cells affects IL-2 signaling and promotes fate decisions, stemness, and protection. Science Immunology 7:eabl6322, 2022.
Chen, M.L., X. Huang, H. Wang, C. Hegner, Y. Liu, J. Shang, A. Eliason, H. Diao, H. Park, B. Frey, G. Wang, S.A. Mosure, L.A. Solt, D.J. Kojetin, A. Rodriguez-Palacios, D.A. Schady, C.T. Weaver, M.E. Pipkin, D.D. Moore, and M.S. Sundrud. CAR directs T cell adaptation to bile acids in the small intestine. Nature 593:147-151, 2021.
Glover ME, Cohen JL, Singer JR, Sabbagh MN, Rainville JR, Hyland MT, Morrow CD, C.T. Weaver, Hodes GE, Kerman IA, and SM Clinton. Examining the role of microbiota in emotional behavior: antibiotic treatment exacerbates anxiety in high-anxiety-prone male rats. Neuroscience, 459:179-197, 2021.
Moldoveanu Z., H. Suzuki, C. Reily, K. Satake, L. Novak, N. Xu, Z.Q. Huang, B. Knoppova, A. Khan, S. Hall, H. Yanagawa, R. Brown, C.J. Winstead, D.B. O'Quinn, A. Weinmann, A.G. Gharavi, K. Kiryluk, B.A. Julian, C.T. Weaver, Y. Suzuki, and J. Novak. Experimental evidence of pathogenic role of IgG autoantibodies in IgA nephropathy. J. Autoimmun. 118:102593, 2021.
C.T. Weaver. One road to the TH17 pathway: How TH1 led to TH17 (and vice versa), and first became last. Nature Immunology 21:819-821, 2020.
Camacho, V., V.R. Matkins, S.B. Patel, J.M.Lever, Z. Yang, L. Ying, A.E. Landuyt, E.C. Dean, J.F. George, H. Yan, P.B. Ferrell, C.L. Maynard, C.T. Weaver, H.R. Turnquist, and R.S. Welner. Bone marrow Tregs mediate stromal cell function and support hematopoiesis via IL-10. J. Clin. Invest. Insight 5:e135681, 2020.
Harbour, S.N., D.F. DiToro, S.J. Witte, C.L. Zindl, T.R. Schoeb, G.W. Jones, S.A. Jones, R.D. Hatton, and C.T. Weaver. Th17 cells require ongoing classical IL-6 receptor signaling to retain transcriptional and functional identity. Science Immunology 5:eeaw2262, 2020.
DiToro, D.F., S.N. Harbour, Steven Witte, Vincent Laufer, M. Gao, C.E. Moseley1, H. Turner, J. Bruning, C.H. Conover,, R.D. Hatton, S.J. Frank5, and C.T. Weaver. Insulin-like growth factors are key regulators of Th17-Treg cell balance in autoimmunity. Immunity 52:650-667, 2020.
Evonuk, K.S., R.E. Doyle, C.E. Moseley, I.M. Thornell, K. Adler, A.M. Bingaman, M.O. Bevensee, B. Min, C.T. Weaver, and T.M. DeSilva. Reduction of AMPA receptor activity on mature oligodendrocytes attenuates loss of myelinated axons in autoimmune neuroinflammatyion. Sci Adv 6:eaax5936, 2020.
Photo: Immunofluorescence photomicrograph demonstrating the intestinal niche of Nippostrongylus brasiliensis, a hookworm that colonizes the mouse gut and is used to model gastrointestinal nematode infections in humans. Photo Credit: Herbert laboratory, University of Pennsylvania School of Veterinary Medicine.