De'Broski R. Herbert PhD

Every cell is an immune cell; contributions of non-hematopoietic cells to anti-helminth immunity. Inclan-Rico JM, Rossi HL, Herbert DR. Mucosal Immunol. 2022 May 10. doi: 10.1038/s41385-022-00518-7. Online ahead of print. PMID: 35538230

Trefoil Factor Family: A Troika for Lung Repair and Regeneration. Rossi HL, Ortiz-Carpena JF, Tucker D, Vaughan AE, Mangalmurti NS, Cohen NA, Herbert DR. Am J Respir Cell Mol Biol. 2021 Nov 16. doi: 10.1165/rcmb.2021-0373TR. PMID: 34784491

Neuroimmune regulatory networks of the airway mucosa in allergic inflammatory disease. Jean EE, Good O, Rico JMI, Rossi HL, Herbert DR. J Leukoc Biol. 2021 Apr 15. doi: 10.1002/JLB.3RU0121-023R. Online ahead of print. PMID: 33857344

Tuft cells in the pathogenesis of chronic rhinosinusitis with nasal polyps and asthma. Sell EA, Ortiz-Carpena JF, Herbert DR, Cohen NA. Ann Allergy Asthma Immunol. 2021 Feb;126(2):143-151. doi: 10.1016/j.anai.2020.10.011. Epub 2020 Oct 26. PMID: 33122124

Oncolytic Myxoma virus infects and damages the tegument of the human parasitic flatworm Schistosoma mansoni. Rahman MM, McFadden G, Ruthel G, Herbert DR, Freedman BD, Greenberg RM, Bais S. Exp Parasitol. 2022 May 19;239:108263. doi: 10.1016/j.exppara.2022.108263. Online ahead of print. PMID: 35598646

Schistosoma mansoni infection induces plasmablast and plasma cell death in the bone marrow and accelerates the decline of host vaccine responses. Musaigwa F, Kamdem SD, Mpotje T, Mosala P, Abdel Aziz N, Herbert DR, Brombacher F, Nono JK. PLoS Pathog. 2022 Feb 14;18(2):e1010327. doi: 10.1371/journal.ppat.1010327. eCollection 2022 Feb. PMID: 35157732

Schistosome TRPML channels play a role in neuromuscular activity and tegumental integrity. Bais S, Norwillo A, Ruthel G, Herbert DR, Freedman BD, Greenberg RM. Biochimie. 2022 Jan 3;194:108-117. doi: 10.1016/j.biochi.2021.12.018 PMID: 34990770

Parasitic helminth infections in humans modulate Trefoil Factor levels in a manner dependent on the species of parasite and age of the host. Adewale B, Heintz JR, Pastore CF, Rossi HL, Hung LY, Rahman N, Bethony J, Diemert D, Babatunde JA, Herbert DR. PLoS Negl Trop Dis. 2021 Oct 18;15(10):e0009550. doi: 10.1371/journal.pntd.0009550. eCollection 2021 Oct. PMID: 34662329

Transgenic expression of a T cell epitope in Strongyloides ratti reveals that helminth-specific CD4+ T cells constitute both Th2 and Treg populations. Douglas B, Wei Y, Li X, Ferguson A, Hung LY, Pastore C, Kurtz JR, McLachlan JB, Nolan TJ, Lok J, Herbert DR. PLoS Pathog. 2021 Jul 8;17(7):e1009709. doi: 10.1371/journal.ppat.1009709. eCollection 2021 Jul. PMID: 34237106

LINGO3 regulates mucosal tissue regeneration and promotes TFF2 dependent recovery from colitis. Zullo KM, Douglas B, Maloney NM, Ji Y, Wei Y, Herbine K, Cohen R, Pastore C, Cramer Z, Wang X, Wei W, Somsouk M, Hung LY, Lengner C, Kohanski MH, Cohen NA, Herbert DR. Scand J Gastroenterol. 2021 Jul;56(7):791-805. doi: 10.1080/00365521.2021.1917650. Epub 2021 May 3. PMID: 33941035

Non-hematopoietic IL-4Rα expression contributes to fructose-driven obesity and metabolic sequelae. Damen MSMA, Stankiewicz TE, Park SH, Helsley RN, Chan CC, Moreno-Fernandez ME, Doll JR, Szabo S, Herbert DR, Softic S, Divanovic S. Int J Obes (Lond). 2021 Nov;45(11):2377-2387. doi: 10.1038/s41366-021-00902-6. Epub 2021 Jul 23. PMID: 34302121

Myeloid-derived interleukin-33 limits the severity of dextran sulfate sodium (DSS)-induced colitis. Hung LY, Pastore CF, Douglas B, Herbert DR. Am J Pathol. 2020 Nov 24:S0002-9440(20)30505-8. doi: 10.1016/j.ajpath.2020.11.004. PMID: 33245913

Cellular context of IL-33 expression dictates impact on anti-helminth immunity. Hung LY, Tanaka Y, Herbine K, Pastore C, Singh B, Ferguson A, Vora N, Douglas B, Zullo K, Behrens EM, Li Hui Tan T, Kohanski MA, Bryce P, Lin C, Kambayashi T, Reed DR, Brown BL, Cohen NA, Herbert DR. Sci Immunol. 2020 Nov 13;5(53):eabc6259. doi: 10.1126/sciimmunol.abc6259. PMID: 33188058

Tuft cells in the pathogenesis of chronic rhinosinusitis with nasal polyps and asthma. Sell EA, Ortiz-Carpena JF, Herbert DR, Cohen NA. Ann Allergy Asthma Immunol. 2020 Oct 26:S1081-1206(20)31144-3. doi: 10.1016/j.anai.2020.10.011. PMID: 33122124 Review

R-spondin 2 mediates neutrophil egress into the alveolar space through increased lung permeability. Jackson, S.R., Costa, M.F.D.M., Pastore, C.F., Zhao, G., Weiner, A.I., Adams, S., Palashikar, G., Quansah, K., Hankenson, K., Herbert, DR, Vaughan, A.E. BMC Res Notes. 2020 Feb 4;13(1):54. doi: 10.1186/s13104-020-4930-8. PMID: 32019591

Photo: Immunofluorescence photomicrograph demonstrating the intestinal niche of Nippostrongylus brasiliensis, a hookworm that colonizes the mouse gut and is used to model gastrointestinal nematode infections in humans. Photo Credit: Herbert laboratory, University of Pennsylvania School of Veterinary Medicine.