Publications
View All Publications (2020 - present)
David Artis, PhD
Arifuzzaman M, Won TH, Li TT, Yano H, Digumarthi S, Heras AF, Zhang W, Parkhurst CN, Kashyap S, Jin WB, Putzel GG, Tsou AM, Chu C, Wei Q, Grier A, JRI IBD Live Cell Bank Consortium, Worgall S, Guo CJ, Schroeder FC, Artis D. Inulin fiber promotes microbiota-derived bile acids and type 2 inflammation. Nature 2022 Nov;611(7936):578-584. doi: 10.1038/s41586-022-05380-y. Epub 2022 Nov 2. PMID: 36323778.
Tsou AM, Yano H, Parkhurst CN1, Mahlakõiv T, Chu C, Zhang W, He Z, Jarick KJ, Zhong C, Putzel GG, Hatazaki M, JRI IBD Live Cell Bank Consortium, Lorenz IC, Andrew D, Balderes P, Klose CSN, Lira SA, Artis D. Neuropeptide regulation of non-redundant ILC2 responses at barrier surfaces. Nature 2022 Nov;611(7937):787-793. doi: 10.1038/s41586-022-05297-6. Epub 2022 Nov 2. PMID: 36323781.
Zhang W, Lyu M, Bessman NJ, Xie Z, Arifuzzaman M, Yano H, Parkhurst CN, Chu C, Zhou L, Putzel GG, Li TT, Jin WB, Zhou J, JRI Live Cell Bank, Hu H, Tsou AM, Guo CJ, Artis D. Gut-innervating nociceptors regulate the intestinal microbiota to promote tissue protection. Cell 2022 Oct 27;185(22):4170-4189.e20. doi: 10.1016/j.cell.2022.09.008. Epub 2022 Oct 14. PMID: 36240781.
Chu C, Parkhurst CN, Zhang W, Zhou L, Yano H, Arifuzzaman M, Artis D. The ChAT-acetylcholine pathway promotes group 2 innate lymphoid cell responses and anti-helminth immunity. Sci Immunol. 2021 Mar 5;6(57):eabe3218. doi: 10.1126/sciimmunol.abe3218. PMID: 33674322
Chung H, Parkhurst CN, Magee EM, Phillips D, Habibi E, Chen F, Yeung BZ, Waldman J, Artis D, Regev A. Joint single-cell measurements of nuclear proteins and RNA in vivo. Nat Methods. 2021 Oct;18(10):1204-1212. doi: 10.1038/s41592-021-01278-1. Epub 2021 Oct 4. PMID: 34608310
Kabata H, Flamar AL, Mahlakõiv T, Moriyama S, Rodewald HR, Ziegler SF, Artis D. Targeted deletion of the TSLP receptor reveals cellular mechanisms that promote type 2 airway inflammation. Mucosal Immunol. 2020 Jul;13(4):626-636. doi: 10.1038/s41385-020-0266-x. Epub 2020 Feb 17. PMID: 32066836
Flamar AL, Klose CSN, Moeller JB, Mahlakõiv T, Bessman NJ, Zhang W, Moriyama S, Stokic-Trtica V, Rankin LC, Putzel GG, Rodewald HR, He Z, Chen L, Lira SA, Karsenty G, Artis D. Interleukin-33 Induces the Enzyme Tryptophan Hydroxylase 1 to Promote Inflammatory Group 2 Innate Lymphoid Cell-Mediated Immunity. Immunity. 2020 Apr 14;52(4):606-619.e6. doi: 10.1016/j.immuni.2020.02.009. Epub 2020 Mar 10. PMID: 32160524.
Monticelli LA, Diamond JM, Saenz SA, Tait Wojno ED, Porteous MK, Cantu E, Artis, D, Christie JD. Innate Lymphoid Cell Composition Is Altered in Primary Graft Dysfunction. Am J Respir Crit Care Med. 2020 Jan 1;201(1):63-72. doi: 10.1164/rccm.201906-1113OC. PMID: 31394048
Review Journals
Klose CSN, Artis D. Innate lymphoid cells control signaling circuits to regulate tissue-specific immunity. Cell Res. 2020 Jun; 30(6): 475 -491. Doi: 10.1038/s41422-020-0323-8. Epub 2020 May 6. PMID: 32376911.
Chu C, Artis D, Chiu IM. Neuro-immune Interactions in the Tissues. Immunity. 2020 Mar 17;52(3):464-474. doi: 10.1016/j.immuni.2020.02.017.PMID: 32187517.
De'Broski R. Herbert PhD
Every cell is an immune cell; contributions of non-hematopoietic cells to anti-helminth immunity. Inclan-Rico JM, Rossi HL, Herbert DR. Mucosal Immunol. 2022 May 10. doi: 10.1038/s41385-022-00518-7. Online ahead of print. PMID: 35538230
Trefoil Factor Family: A Troika for Lung Repair and Regeneration. Rossi HL, Ortiz-Carpena JF, Tucker D, Vaughan AE, Mangalmurti NS, Cohen NA, Herbert DR. Am J Respir Cell Mol Biol. 2021 Nov 16. doi: 10.1165/rcmb.2021-0373TR. PMID: 34784491
Neuroimmune regulatory networks of the airway mucosa in allergic inflammatory disease. Jean EE, Good O, Rico JMI, Rossi HL, Herbert DR. J Leukoc Biol. 2021 Apr 15. doi: 10.1002/JLB.3RU0121-023R. Online ahead of print. PMID: 33857344
Tuft cells in the pathogenesis of chronic rhinosinusitis with nasal polyps and asthma. Sell EA, Ortiz-Carpena JF, Herbert DR, Cohen NA. Ann Allergy Asthma Immunol. 2021 Feb;126(2):143-151. doi: 10.1016/j.anai.2020.10.011. Epub 2020 Oct 26. PMID: 33122124
Oncolytic Myxoma virus infects and damages the tegument of the human parasitic flatworm Schistosoma mansoni. Rahman MM, McFadden G, Ruthel G, Herbert DR, Freedman BD, Greenberg RM, Bais S. Exp Parasitol. 2022 May 19;239:108263. doi: 10.1016/j.exppara.2022.108263. Online ahead of print. PMID: 35598646
Schistosoma mansoni infection induces plasmablast and plasma cell death in the bone marrow and accelerates the decline of host vaccine responses. Musaigwa F, Kamdem SD, Mpotje T, Mosala P, Abdel Aziz N, Herbert DR, Brombacher F, Nono JK. PLoS Pathog. 2022 Feb 14;18(2):e1010327. doi: 10.1371/journal.ppat.1010327. eCollection 2022 Feb. PMID: 35157732
Schistosome TRPML channels play a role in neuromuscular activity and tegumental integrity. Bais S, Norwillo A, Ruthel G, Herbert DR, Freedman BD, Greenberg RM. Biochimie. 2022 Jan 3;194:108-117. doi: 10.1016/j.biochi.2021.12.018 PMID: 34990770
Parasitic helminth infections in humans modulate Trefoil Factor levels in a manner dependent on the species of parasite and age of the host. Adewale B, Heintz JR, Pastore CF, Rossi HL, Hung LY, Rahman N, Bethony J, Diemert D, Babatunde JA, Herbert DR. PLoS Negl Trop Dis. 2021 Oct 18;15(10):e0009550. doi: 10.1371/journal.pntd.0009550. eCollection 2021 Oct. PMID: 34662329
Transgenic expression of a T cell epitope in Strongyloides ratti reveals that helminth-specific CD4+ T cells constitute both Th2 and Treg populations. Douglas B, Wei Y, Li X, Ferguson A, Hung LY, Pastore C, Kurtz JR, McLachlan JB, Nolan TJ, Lok J, Herbert DR. PLoS Pathog. 2021 Jul 8;17(7):e1009709. doi: 10.1371/journal.ppat.1009709. eCollection 2021 Jul. PMID: 34237106
LINGO3 regulates mucosal tissue regeneration and promotes TFF2 dependent recovery from colitis. Zullo KM, Douglas B, Maloney NM, Ji Y, Wei Y, Herbine K, Cohen R, Pastore C, Cramer Z, Wang X, Wei W, Somsouk M, Hung LY, Lengner C, Kohanski MH, Cohen NA, Herbert DR. Scand J Gastroenterol. 2021 Jul;56(7):791-805. doi: 10.1080/00365521.2021.1917650. Epub 2021 May 3. PMID: 33941035
Non-hematopoietic IL-4Rα expression contributes to fructose-driven obesity and metabolic sequelae. Damen MSMA, Stankiewicz TE, Park SH, Helsley RN, Chan CC, Moreno-Fernandez ME, Doll JR, Szabo S, Herbert DR, Softic S, Divanovic S. Int J Obes (Lond). 2021 Nov;45(11):2377-2387. doi: 10.1038/s41366-021-00902-6. Epub 2021 Jul 23. PMID: 34302121
Myeloid-derived interleukin-33 limits the severity of dextran sulfate sodium (DSS)-induced colitis. Hung LY, Pastore CF, Douglas B, Herbert DR. Am J Pathol. 2020 Nov 24:S0002-9440(20)30505-8. doi: 10.1016/j.ajpath.2020.11.004. PMID: 33245913
Cellular context of IL-33 expression dictates impact on anti-helminth immunity. Hung LY, Tanaka Y, Herbine K, Pastore C, Singh B, Ferguson A, Vora N, Douglas B, Zullo K, Behrens EM, Li Hui Tan T, Kohanski MA, Bryce P, Lin C, Kambayashi T, Reed DR, Brown BL, Cohen NA, Herbert DR. Sci Immunol. 2020 Nov 13;5(53):eabc6259. doi: 10.1126/sciimmunol.abc6259. PMID: 33188058
Tuft cells in the pathogenesis of chronic rhinosinusitis with nasal polyps and asthma. Sell EA, Ortiz-Carpena JF, Herbert DR, Cohen NA. Ann Allergy Asthma Immunol. 2020 Oct 26:S1081-1206(20)31144-3. doi: 10.1016/j.anai.2020.10.011. PMID: 33122124 Review
R-spondin 2 mediates neutrophil egress into the alveolar space through increased lung permeability. Jackson, S.R., Costa, M.F.D.M., Pastore, C.F., Zhao, G., Weiner, A.I., Adams, S., Palashikar, G., Quansah, K., Hankenson, K., Herbert, DR, Vaughan, A.E. BMC Res Notes. 2020 Feb 4;13(1):54. doi: 10.1186/s13104-020-4930-8. PMID: 32019591
Chyi-Song Hsieh, MD, PhD
Yi J, Miller AT, Archambault AS, Jones AJ, Bradstreet TR, Bandla S, Hsu YS, Edelson BT, Zhou YW, Fremont DH, Egawa T, Singh S, Wu GF, Hsieh CS. Antigen-specific depletion of CD4 T cells by CAR T cells reveals distinct roles of higher and lower affinity TCRs during autoimmunity (2022). Science Immunology, in press.
Russler-Germain EV, Jung J, Miller AT, Young S, Yi J, Wehmeier A, Fox LE, Monte KJ, Chai JN, Kulkarni DH, Funkhouser-Jones LJ, Wilke G, Durai V, Zinselmeyer BH, Czepielewski RS, Greco S, Murphy KM, Newberry RD, Sibley LD, Hsieh CS. Commensal Cryptosporidium colonization drives cDC1-dependent intestinal Th1-mediated homeostasis (2021). Immunity 54(11):2547-2564. PMCID: PMC8716016
Russler-Germain EV, Yi J, Young S, Nutsch K, Wong HS, Ai TL, Chai JN, Durai V, Kaplan DH, Germain RN, Murphy KM, Hsieh CS. Gut Helicobacter Presentation by Multiple Dendritic Cell Subsets Enables Context-Specific Regulatory T Cell Generation (2021). eLife 10:e54792. PMCID: PMC7877908
Hsieh CS, Rengarajan S, Kau A, Tarazona-Meza C, Nicholson A, Checkley W, Romero K, Hansel NN. Altered IgA Response to Gut Bacteria Is Associated with Childhood Asthma in Peru (2021). J Immunol. 207(2):398-407. PMID: 34193598; PMCID: PMC8516662.
Rengarajan S, Knoop KA, Rengarajan A, Chai JN, Grajales-Reyes JG, Samineni VK, Russler-Germain EV, Ranganathan P, Fasano A, Sayuk GS, Gereau IV RW, Kau AL, Knights D, Kashyap PC, Ciorba MA, Newberry RD, Hsieh CS. A potential role for stress-induced microbial alterations in IgA-associated irritable bowel syndrome with diarrhea (2020). Cell Reports Med. 1: 100124. PMCID: PMC7659537
Rengarajan S, Vivio EE, Parkes M, Peterson DA, Roberson EDO, Newberry RD, Ciorba MA, Hsieh CS. Dynamic immunoglobulin responses to gut bacteria during inflammatory bowel disease (2020). Gut Microbes 11:405.
Christopher A. Hunter, Ph.D.
Doke T, Abedini A, Aldridge DL, Yang YW, Park J, Hernandez CM, Balzer MS, Shrestra R, Coppock G, Rico JMI, Han SY, Kim J, Xin S, Piliponsky AM, Angelozzi M, Lefebvre V, Siracusa MC, Hunter CA, Susztak K. 2022. Single-cell analysis identifies the interaction of altered renal tubules with basophils orchestrating kidney fibrosis. Nat Immunol 23: 947-59
Gibson AR, Sateriale A, Dumaine JE, Engiles JB, Pardy RD, Gullicksrud JA, O'Dea KM, Doench JG, Beiting DP, Hunter CA, Striepen B. 2022. A genetic screen identifies a protective type III interferon response to Cryptosporidium that requires TLR3 dependent recognition. PLoS Pathog 18: e1010003
Christian DA, Adams TA, 2nd, Shallberg LA, Phan AT, Smith TE, Abraha M, Perry J, Ruthel G, Clark JT, Pritchard GH, Aronson LR, Gossa S, McGavern DB, Kedl RM, Hunter CA. 2022. cDC1 coordinate innate and adaptive responses in the omentum required for T cell priming and memory. Sci Immunol 7: eabq7432
Shallberg LA, Phan AT, Christian DA, Perry JA, Haskins BE, Beiting DP, Harris TH, Koshy AA, Hunter CA. 2022. Impact of secondary TCR engagement on the heterogeneity of pathogen-specific CD8+ T cell response during acute and chronic toxoplasmosis. PLoS Pathog 18: e1010296
Perry JA, Shallberg L, Clark JT, Gullicksrud JA, DeLong JH, Douglas BB, Hart AP, Lanzar Z, O'Dea K, Konradt C, Park J, Kuchroo JR, Grubaugh D, Zaretsky AG, Brodsky IE, Malefyt RD, Christian DA, Sharpe AH, Hunter CA. 2022. PD-L1-PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection. Nature Immunology 23: 743-+
Clark JT, Christian DA, Gullicksrud JA, Perry JA, Park J, Jacquet M, Tarrant JC, Radaelli E, Silver J, Hunter CA. 2021. IL-33 promotes innate lymphoid cell-dependent IFN-gamma production required for innate immunity to Toxoplasma gondii. Elife 10: doi: 10.7554/eLife.65614
Sateriale A, Gullicksrud JA, Engiles JB, McLeod BI, Kugler EM, Henao-Mejia J, Zhou T, Ring AM, Brodsky IE, Hunter CA, Striepen B. 2021. The intestinal parasite Cryptosporidium is controlled by an enterocyte intrinsic inflammasome that depends on NLRP6. Proc Natl Acad Sci U S A 118
Gullicksrud JA, Sateriale A, Engiles JB, Gibson AR, Shaw S, Hutchins ZA, Martin L, Christian DA, Taylor GA, Yamamoto M, Beiting DP, Striepen B, Hunter CA. 2021. Enterocyte-innate lymphoid cell crosstalk drives early IFN-gamma-mediated control of Cryptosporidium. Mucosal Immunol
Lam LKM, Murphy S, Kokkinaki D, Venosa A, Sherrill-Mix S, Casu C, Rivella S, Weiner A, Park J, Shin S, Vaughan AE, Hahn BH, Odom John AR, Meyer NJ, Hunter CA, Worthen GS, Mangalmurti NS. 2021. DNA binding to TLR9 expressed by red blood cells promotes innate immune activation and anemia. Sci Transl Med 13: eabj1008
Aldridge DL, Phan AT, de Waal Malefyt R, Hunter CA. 2021. Limited Impact of the Inhibitory Receptor TIGIT on NK and T Cell Responses during Toxoplasma gondii Infection. Immunohorizons 5: 384-94
Ivaylo Ivanov, Ph.D.
Kawano Y, Edwards M, Huang Y, Bilate AM, Araujo LP, Tanoue T, Atarashi K, Ladinsky MS, Reiner SL, Wang HH, Mucida D, Honda K, Ivanov II. Dietary sugar-induced microbiota imbalance disrupts immune-mediated protection from metabolic syndrome. Cell 2022 Sep 15;185(19):3501-3519.e20. PMID: 36041436.
Ivanov II, Tuganbaev T, Skelly AN, Honda K. T cell responses to the microbiota. Annual Review of Immunology. 2022 Feb 3. PMID: 35113732
Zhang X, Bandyopadhyay S, Araujo LP, Tong K, Flores J, Laubitz D, Zhao Y, Yap G, Wang J, Zou Q, Ferraris R, Zhang L, Hu W, Bonder EM, Kiela PR, Coffey R, Verzi MP, Ivanov II, Gao N. Elevating EGFR-MAPK program by a nonconventional Cdc42 enhances intestinal epithelial survival and regeneration. JCI Insight. 2020 Aug 20;5(16):135923. PMID 32686657
Ladinsky MS, Araujo LP, Zhang X, Veltri J, Galan-Diez M, Soualhi S, Lee C, Irie K, Pinker E, Narushima S, Bandyopadhyay S, Nagayama M, Elhenawy W, Coombes BK, Ferraris RP, Honda K, Iliev ID, Gao N, Bjorkman PJ, Ivanov II. Endocytosis of commensal antigens by intestinal epithelial cells regulates mucosal T cell homeostasis. Science 2019 Mar 9;363(6431). PMID 30846568
Rodney D. Newberry, M.D.
Udayan S, Stamou P, Crispie F, Hickey A, Floyd AN, Hsieh CS, Cotter PD, O'Sullivan O, Melgar S, O'Toole PW, Newberry RD, Rossini V, Nally K. Identification of Gut Bacteria such as Lactobacillus johnsonii that Disseminate to Systemic Tissues of Wild Type and MyD88-/- Mice. Gut microbes. 2022;14(1):2007743. doi: 10.1080/19490976.2021.2007743. PubMed PMID: 35023810; PMCID: PMC8765072.
Sazonovs A, Stevens CR, Venkataraman GR, Yuan K, Avila B, Abreu MT, Ahmad T, Allez M, Ananthakrishnan AN, Atzmon G, Baras A, Barrett JC, Barzilai N, Beaugerie L, Beecham A, Bernstein CN, Bitton A, Bokemeyer B, Chan A, Chung D, Cleynen I, Cosnes J, Cutler DJ, Daly A, Damas OM, Datta LW, Dawany N, Devoto M, Dodge S, Ellinghaus E, Fachal L, Farkkila M, Faubion W, Ferreira M, Franchimont D, Gabriel SB, Ge T, Georges M, Gettler K, Giri M, Glaser B, Goerg S, Goyette P, Graham D, Hämäläinen E, Haritunians T, Heap GA, Hiltunen M, Hoeppner M, Horowitz JE, Irving P, Iyer V, Jalas C, Kelsen J, Khalili H, Kirschner BS, Kontula K, Koskela JT, Kugathasan S, Kupcinskas J, Lamb CA, Laudes M, Lévesque C, Levine AP, Lewis JD, Liefferinckx C, Loescher BS, Louis E, Mansfield J, May S, McCauley JL, Mengesha E, Mni M, Moayyedi P, Moran CJ, Newberry RD, O'Charoen S, Okou DT, Oldenburg B, Ostrer H, Palotie A, Paquette J, Pekow J, Peter I, Pierik MJ, Ponsioen CY, Pontikos N, Prescott N, Pulver AE, Rahmouni S, Rice DL, Saavalainen P, Sands B, Sartor RB, Schiff ER, Schreiber S, Schumm LP, Segal AW, Seksik P, Shawky R, Sheikh SZ, Silverberg MS, Simmons A, Skeiceviciene J, Sokol H, Solomonson M, Somineni H, Sun D, Targan S, Turner D, Uhlig HH, van der Meulen AE, Vermeire S, Verstockt S, Voskuil MD, Winter HS, Young J, Duerr RH, Franke A, Brant SR, Cho J, Weersma RK, Parkes M, Xavier RJ, Rivas MA, Rioux JD, McGovern DPB, Huang H, Anderson CA, Daly MJ. Large-scale sequencing identifies multiple genes and rare variants associated with Crohn's disease susceptibility. Nat Genet. 2022. Epub 20220829. doi: 10.1038/s41588-022-01156-2. PubMed PMID: 36038634.
Yokanovich LT, Newberry RD, Knoop KA. Regulation of oral antigen delivery early in life: Implications for oral tolerance and food allergy. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2021. Epub 2021/01/07. doi: 10.1111/cea.13823. PubMed PMID: 33403739.
Wang MH, Friton JJ, Raffals LE, Leighton JA, Pasha SF, Picco MF, Monroe K, Nix BD, Newberry RD, Faubion WA. Novel Genetic Variant Predicts Surgical Recurrence Risk in Crohn's Disease Patients. Inflamm Bowel Dis. 2021. Epub 2021/03/17. doi: 10.1093/ibd/izaa362. PubMed PMID: 33724339.
Somineni HK, Nagpal S, Venkateswaran S, Cutler DJ, Okou DT, Haritunians T, Simpson CL, Begum F, Datta LW, Quiros AJ, Seminerio J, Mengesha E, Alexander JS, Baldassano RN, Dudley-Brown S, Cross RK, Dassopoulos T, Denson LA, Dhere TA, Iskandar H, Dryden GW, Hou JK, Hussain SZ, Hyams JS, Isaacs KL, Kader H, Kappelman MD, Katz J, Kellermayer R, Kuemmerle JF, Lazarev M, Li E, Mannon P, Moulton DE, Newberry RD, Patel AS, Pekow J, Saeed SA, Valentine JF, Wang MH, McCauley JL, Abreu MT, Jester T, Molle-Rios Z, Palle S, Scherl EJ, Kwon J, Rioux JD, Duerr RH, Silverberg MS, Zwick ME, Stevens C, Daly MJ, Cho JH, Gibson G, McGovern DPB, Brant SR, Kugathasan S. Whole-genome sequencing of African Americans implicates differential genetic architecture in inflammatory bowel disease. Am J Hum Genet. 2021;108(3):431-45. Epub 2021/02/19. doi: 10.1016/j.ajhg.2021.02.001. PubMed PMID: 33600772; PMCID: PMC8008495.
Secca C, Bando JK, Fachi JL, Gilfillan S, Peng V, Di Luccia B, Cella M, McDonald KG, Newberry RD, Colonna M. Spatial distribution of LTi-like cells in intestinal mucosa regulates type 3 innate immunity. Proc Natl Acad Sci U S A. 2021;118(23). Epub 2021/06/05. doi: 10.1073/pnas.2101668118. PubMed PMID: 34083442; PMCID: PMC8201890.
Russler-Germain EV, Jung J, Miller AT, Young S, Yi J, Wehmeier A, Fox LE, Monte KJ, Chai JN, Kulkarni DH, Funkhouser-Jones LJ, Wilke G, Durai V, Zinselmeyer BH, Czepielewski RS, Greco S, Murphy KM, Newberry RD, Sibley LD, Hsieh CS. Commensal Cryptosporidium colonization elicits a cDC1-dependent Th1 response that promotes intestinal homeostasis and limits other infections. Immunity. 2021;54(11):2547-64.e7. Epub 2021/10/30. doi: 10.1016/j.immuni.2021.10.002. PubMed PMID: 34715017; PMCID: PMC8716016.
Rusconi BA, Newberry RD. The microbial one-hit wonder. J Exp Med. 2021;218(9). Epub 2021/08/20. doi: 10.1084/jem.20211382. PubMed PMID: 34410326; PMCID: PMC8383817.
Noah TK, Lee JB, Brown CA, Yamani A, Tomar S, Ganesan V, Newberry RD, Huffnagle GB, Divanovic S, Hogan SP. Thermoneutrality Alters Gastrointestinal Antigen Passage Patterning and Predisposes to Oral Antigen Sensitization in Mice. Frontiers in immunology. 2021;12:636198. Epub 2021/04/13. doi: 10.3389/fimmu.2021.636198. PubMed PMID: 33841417; PMCID: PMC8034294.
Newberry RD, Hogan SP. Intestinal epithelial cells in tolerance and allergy to dietary antigens. The Journal of allergy and clinical immunology. 2021;147(1):45-8. Epub 2020/11/05. doi: 10.1016/j.jaci.2020.10.030. PubMed PMID: 33144143.
Kulkarni DH, Newberry RD. A Novel Role of Circular RNA in Intestinal Epithelial Repair. Gastroenterology. 2021;161(4):1108-10. Epub 2021/07/26. doi: 10.1053/j.gastro.2021.07.031. PubMed PMID: 34303659.
Kosinsky RL, Zerche M, Kutschat AP, Nair A, Ye Z, Saul D, von Heesen M, Friton JJ, Schwarzer AC, Paglilla N, Sheikh SZ, Wegwitz F, Sun Z, Ghadimi M, Newberry RD, Sartor RB, Faubion WA, Johnsen SA. RNF20 and RNF40 regulate vitamin D receptor-dependent signaling in inflammatory bowel disease. Cell Death Differ. 2021. Epub 2021/06/06. doi: 10.1038/s41418-021-00808-w. PubMed PMID: 34088983.
Ingle H, Hassan E, Gawron J, Mihi B, Li Y, Kennedy EA, Kalugotla G, Makimaa H, Lee S, Desai P, McDonald KG, Diamond MS, Newberry RD, Good M, Baldridge MT. Murine astrovirus tropism for goblet cells and enterocytes facilitates an IFN-lambda response in vivo and in enteroid cultures. Mucosal Immunol. 2021;14(3):751-61. Epub 2021/03/07. doi: 10.1038/s41385-021-00387-6. PubMed PMID: 33674763; PMCID: PMC8085034.
Gustafsson JK, Davis JE, Rappai T, McDonald KG, Kulkarni DH, Knoop KA, Hogan SP, Fitzpatrick JA, Lencer WI, Newberry RD. Intestinal goblet cells sample and deliver lumenal antigens by regulated endocytic uptake and transcytosis. Elife. 2021;10. Epub 2021/10/23. doi: 10.7554/eLife.67292. PubMed PMID: 34677124; PMCID: PMC8594945.
Courtney CM, Onufer EJ, McDonald KG, Steinberger AE, Sescleifer AM, Seiler KM, Tecos ME, Newberry RD, Warner BW. Small Bowel Resection Increases Paracellular Gut Barrier Permeability via Alterations of Tight Junction Complexes Mediated by Intestinal TLR4. J Surg Res. 2021;258:73-81. Epub 20200928. doi: 10.1016/j.jss.2020.08.049. PubMed PMID: 33002664; PMCID: PMC7937530.
Matthew E. Pipkin, Ph.D.
Diao H, Chen R, Tsuda SM, Wang D, Frederick MA, Kim J, Karunadharma P, Martinez GJ, Getzler AJ, Toma C, Milner JJ, Venables TC, Martin DM, Goldrath AW, Crotty S, Pipkin ME. Single-cell lineage trajectories and chromatin regulators that initialize antiviral CD8 T cell ontogeny. In revision. Available via bioRxiv: https://doi.org/10.1101/2021.08.11.456014
Milner JJ, Toma C, Quon S, Omilusik K, Scharping NE, Dey A, Reina-Campos M, Nguyen H, Getzler AJ, Diao H, Yu B, Delpoux A, Yoshida TM, Li D, Qi J, Vincek A, Hedrick SM, Egawa T, Zhou MM, Crotty S, Ozato K, Pipkin ME, Goldrath AW. Bromodomain protein BRD4 directs and sustains CD8 T cell differentiation during infection. J Exp Med. 2021 Aug 2;218(8):e20202512. doi: 10.1084/jem.20202512. PMID: 34037670
Tsuda S, Pipkin ME. Transcriptional Control of Cell Fate Determination in Antigen-Experienced CD8 T Cells. Cold Spring Harb Perspect Biol. 2021 Jun 14:a037945. doi: 10.1101/cshperspect.a037945. PMID: 34127445
Xu T, Schutte A, Jimenez L, Gonçalves ANA, Keller A, Pipkin ME, Nakaya HI, Pereira RM, Martinez GJ. Kdm6b Regulates the Generation of Effector CD8 + T Cells by Inducing Chromatin Accessibility in Effector-Associated Genes. J Immunol. 2021 May 1;206(9):2170-2183. doi: 10.4049/jimmunol.2001459. Epub 2021 Apr 16. PMID: 33863789.
Chen ML, Huang X, Wang H, Hegner C, Liu Y, Shang J, Eliason A, Diao H, Park H, Frey B, Wang G, Mosure SA, Solt SA, Kojetin DJ, Rodriguez-Palacios A, Schady DA, Weaver CT, Pipkin ME, Moore DD*, and Sundrud MS*. CAR directs T cell adaptation to bile acids in the small intestine. Nature, 2021 April 7. doi: 10.1038/s41586-021-03421-6. PMID: 33828301.
Pipkin ME. Runx proteins and transcriptional mechanisms that govern memory CD8 T cell development. Immunol Rev. 2021 Mar;300(1):100-124. doi: 10.1111/imr.12954. PMID: 33682165
Mori L, Jenike K, Yeh YHJ , Lacombe B, Li C, Getzler A, Mediouni S, Cameron M, Pipkin ME, Ho YC, Ramirez BC, Valente S. The XPB Subunit of the TFIIH Complex Plays a Critical Role in HIV-1 Transcription and XPB Inhibition by Spironolactone Prevents HIV-1 Reactivation from Latency. J Virol. 2020 Nov 25;95(4):e01247-20. doi: 10.1128/JVI.01247-20
Choi J, Diao H, Faliti CE, Truong J, Rossi M, Bélanger S, Yu B, Goldrath AW, Pipkin ME, Crotty S. Bcl-6 is the nexus transcription factor of T follicular helper cells via repressor-of-repressor circuits. Nat Immunol. 2020 Jul;21(7):777-789. doi: 10.1038/s41590-020-0706-5. PubMed PMID: 32572238.
Gwendalyn J. Randolph, PhD.
Uzzan M, Martin JC, Mesin L, Livanos AE, Castro-Dopico T, Huang R, Petralia F, Magri G, Kumar S, Zhao Q, Rosenstein AK, Tokuyama M, Sharma K, Ungaro R, Kosoy R, Jha D, Fischer J, Singh H, Keir ME, Ramamoorthi N, Gorman WEO, Cohen BL, Rahman A, Cossarini F, Seki A, Leyre L, Vaquero ST, Gurunathan S, Grasset EK, Losic B, Dubinsky M, Greenstein AJ, Gottlieb Z, Legnani P, George J, Irizar H, Stojmirovic A, Brodmerkel C, Kasarkis A, Sands BE, Furtado G, Lira SA, Tuong ZK, Ko HM, Cerutti A, Elson CO, Clatworthy MR, Merad M, Suárez-Fariñas M, Argmann C, Hackney JA, Victora GD, Randolph GJ, Kenigsberg E, Colombel JF, Mehandru S. Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity. Nat Med. 2022 Apr;28(4):766-779. doi: 10.1038/s41591-022-01680-y.
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Han YH, Onufer EJ, Sprung RW, Davidson WS, Czepielewski RS, Wohltmann M, Sorci-Thomas MG, Warner BW, Randolph GJ. 2021. Enterically derived high-density lipoprotein restrains liver injury through the portal vein. Science, 373, 410; DOI: 10.1126/science.abe6729. [Feature articles in Immunity, and Nature Rev Gastro Hepatol]
Baba O, Elvington A, Sultan D, Heo GS, Zhang X, Luehmann H, Detering L, Szpakowska M, Chevigne A, Liu Y, Randolph GJ. 2021. CXCR4 on atherosclerotic plaque endothelium predicts the magnitude of monocyte recruitment and is readily targeted by PET tracers. Arterio Thromb Vasc Biol 41(2):822-836. doi: 10.1161/ATVBAHA.120.315053. [editorial comment, same issue]
Huang LH, Deepak P, Ciorba MA, Mittendorfer B, Patterson BW, Randolph GJ. 2020. Postprandial chylomicron output and transport through intestinal lymphatics are not impaired in active Crohn's disease. Gastroenterology, 159:1955-9156. doi: 10.1053/j.gastro.2020.07.012. [letter to the editor published, along with our reply, April 2021]
Williams JW, Zaitsev K, Kim KW, Ivanov S, Saunders BT, Schrank PR, Kim K, Elvington A, Kim SH, Tucker C, Wohltmann M, Fife BT, Epelman S, Artyomov M, Lavine KJ, Zinselmeyer BH, Choi JH, Randolph GJ. Limited proliferation capacity of aorta intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression. Nature Immunology, 21:1194-1204. doi. 10.1038/s41590-020-0768-4
Boris Striepen, PhD
Gibson A.R., Sateriale A., Dumaine J.E., Engiles J.B., Pardy R.D., Gullicksrud J.A., O'Dea, K., Beiting, D. P., Hunter, C.A., and Striepen, B. (2022) A genetic screen identifies a protective type III interferon response to Cryptosporidium that requires TLR3 dependent recognition. PLoS Pathogens 18: e1010003.
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Guérin, A., Roy, N.H., Kugler, E.M., Berry, L., Burkhardt, J.K., Shin, J.-B., and Striepen, B. (2021) A screen for Cryptosporidium rhoptry proteins identifies ROP1 as an effector targeting the host cytoskeletal modulator LMO7. Cell Host & Microbe 29: 1-14.
Sateriale, A., Gullicksrud, J.A., Engiles, J.B., McLeod, B., Kugler, E.M., Henao-Mejia, J., Zhou, T., Ring, A.M., Brodsky, I.E., J.C. Hunter, C.A., and Striepen, B. (2021) The intestinal parasite Cryptosporidium is controlled by an enterocyte intrinsic inflammasome that depends on NLRP6. Proc. Natl. Acad. Sci. U.S.A. 118: e2007807118.
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Pawlowic, M., Somepalli, M., Sateriale, A., Herbert, G.T. Gibson, A.R., Cuny, G., Hedstrom, L., and Striepen, B. (2019) Genetic ablation of purine salvage in Cryptosporidium parvum reveals nucleotide uptake from the host cell. Proc. Natl. Acad. Sci. U.S.A. 116: 21160-21165.
Tandel, J., English, E., Sateriale, A., Gullicksrud, J., Beiting, D.P., Sullivan, M.C., Pinkston, B., and Striepen, B. (2019) Lifecycle progression and sexual development of the apicomplexan parasite Cryptosporidium parvum. Nature Microbiology 4: 2226-2236
Sateriale, A., Slapeta, J., Baptista, R., Engiles, J.B., Gullicksrud, J.A., Herbert, G.T., Brooks, C.F., Kugler, E.M., Kissinger, J.C. Hunter, C.A., and Striepen, B. (2019) A genetically tractable, natural mouse model of cryptosporidiosis offers insights into host protective immunity. Cell Host & Microbe 26, 135–146
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Vinayak, S.*, Pawlowic, M.C.*, Sateriale, A*, Brooks, C.F., Studstill, J.C., Bar-Peled, Y., Cirpriano, M.J. and Striepen, B. (2015) Genetic modification of the diarrheal pathogen Cryptosporidium parvum. Nature 523: 477–480 (*equal contribution)
Gregory F. Sonnenberg, PhD
Lyu M, Suzuki H, Kang L, Gaspal F, Zhou W, Goc J, Zhou L, Zhou J, Zhang W, JRI Live Cell Bank, Shen Z, Fox JG, Sockolow RE, Laufer TM, Fan Y, Eberl G, Withers DR, Sonnenberg GF. ILC3s select microbiota-specific regulatory T cells to establish tolerance in the gut. Nature. 2022.
Zhou W, Zhou L, Zhou J; JRI Live Cell Bank, Chu C, Zhang C, Sockolow RE, Eberl G, Sonnenberg GF. ZBTB46 defines and regulates ILC3s that protect the intestine. Nature. 2022 Jul 13. doi: 10.1038/s41586-022-04934-4. Epub ahead of print. PMID: 35831503.
Zhou JZ, Sonnenberg GF. Coordination of Mucosal Immunity by Innate Lymphoid Cells. Adv Exp Med Biol. 2022;1365:113-134. doi: 10.1007/978-981-16-8387-9_8. PMID: 35567744.
Zhou L, Zhou W, Joseph AM, Chu C, Putzel GG, Fang B, Teng F, Lyu M, Yano H, Andreasson KI, Mekada E, Eberl G, Sonnenberg GF. Group 3 innate lymphoid cells produce the growth factor HB-EGF to protect the intestine from TNF-mediated inflammation. Nature Immunology. 2022 Jan 31. doi: 10.1038/s41590-021-01110-0. PMID: 35102343.
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Goc J, Lv M, Bessman NJ, Flamar A, Sahota S, Suzuki H, Teng F, Putzel GG, JRI Live Cell Bank, Eberl G, Withers DR, Arthur JC, Shah MA, Sonnenberg GF. Dysregulation of ILC3s unleashes progression and immunotherapy resistance in colon cancer. Cell. 2021. Sep 16;184(19):5015-5030.e16. doi: 10.1016/j.cell.2021.07.029. PubMed PMID: 34407392
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Mark S. Sundrud, Ph.D.
MT Abreu, JM Davies, MA Quintero, A Delmas, S Diaz, CD Martinez, T Venables, A Reich, G Crynen, A Deshpande, DH Kerman, OM Damas, I Fernandez, AM Santander, J Pignac-Kobinger, JF Burgueno, MS Sundrud. 2021. Transcriptional behavior of regulatory T cells predicts IBD patient responses to vedolizumab therapy. IBD Journal – in press.
ML Chen, X Huang, H Wang, Y Liu, J Shang, A Eliason, C Hegner, H Park, B Frey, G Wang, DJ Kojetin, CT Weaver, ME Pipkin, DD Moore, MS Sundrud. 2021. CAR directs T cell adaptation to bile acids in the small intestine. Nature. May;593(7857):147-151. doi: 10.1038/s41586-021-03421-6. Epub 2021 Apr 7.
R Wang, S Campbell, M Amir, MA Bassette, A Eliason, MS Sundrud, TM Kamenecka, LA Solt. 2021. Genetic and pharmacological inhibition of the nuclear receptor RORa regulates TH17 driven inflammatory disorders. Nat Comm. Jan 4;12(1):76.
AR Basson, C Chen, F Sagl, A Trotter, I Bederman, A Gomez-Nguyen, MS Sundrud, S Ilic, F Cominelli, A Rodriguez-Palacios. Regulation of Intestinal Inflammation by Dietary Fats. Front Immunol. 2021 Feb 2;11:604989. doi: 10.3389/fimmu.2020.604989. eCollection 2020.
ML Chen, A Sun, W Cao, A Eliason, KM Mendez, AJ Getzler, S Tsuda, H Diao, C Mukori, NE Bruno, SY Kim, ME Pipkin, SB Koralov, MS Sundrud. 2020. Physiologic expression and function of the multidrug transporter MDR1 in cytotoxic T lymphocytes. J Exp Med. May 4;217(5):e20191388.
Y Kim, MS Sundrud, C Zhou, M Edenius, D Zocco, K Powers, EH Noss, MB Brenner, A Rao, R Mazitschek, CY Yeo, M Whitman, TL Keller. 2020. Aminoacyl-tRNA Synthetase Inhibition Activates a Novel Pathway that Branches from the Canonical Amino Acid Response in Mammalian Cells. Proc Natl Acad Sci USA. Apr 21;117(16):8900-8911. #co-first author.
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Casey T. Weaver, MD
Pham, D., D.J. Silberger, M. Gao, K.N. Nguyen, R.D. Hatton+, and C.T Weaver+. Batf stabilizes the Th17 cell developmental program through impairment of Stat5-dependent recruitment of Ets1-Runx1 complexes. EMBO J (in revision).
Zindl, C.L., S.J. Witte, V.A. Laufer, M. Gao, Z. Yue, Daniel J. Silberger, S.N. Harbour, J.R. Singer, Duy Pham, C.E. Moseley, B. Cai, H. Turner, F.E. Lund, B.A. Vallance, A.F. Rosenberg, J.Y. Chen, R.T. Hatton1 and C.T. Weaver. A non-redundant role for T cell-derived IL-22 in antibacterial defense of colonic crypts. Immunity 55:494-511, 2022.
Kahan. S.M., R.K. Bakshi, J.T. Ingram, R.C. Hendrickson, E.J. Lefkowitz, D.K. Crossman, L.E. Harrington, C.T. Weaver, and A.J. Zajac. Intrinsic IL-2 production by effector CD8 T cells affects IL-2 signaling and promotes fate decisions, stemness, and protection. Science Immunology 7:eabl6322, 2022.
Chen, M.L., X. Huang, H. Wang, C. Hegner, Y. Liu, J. Shang, A. Eliason, H. Diao, H. Park, B. Frey, G. Wang, S.A. Mosure, L.A. Solt, D.J. Kojetin, A. Rodriguez-Palacios, D.A. Schady, C.T. Weaver, M.E. Pipkin, D.D. Moore, and M.S. Sundrud. CAR directs T cell adaptation to bile acids in the small intestine. Nature 593:147-151, 2021.
Glover ME, Cohen JL, Singer JR, Sabbagh MN, Rainville JR, Hyland MT, Morrow CD, C.T. Weaver, Hodes GE, Kerman IA, and SM Clinton. Examining the role of microbiota in emotional behavior: antibiotic treatment exacerbates anxiety in high-anxiety-prone male rats. Neuroscience, 459:179-197, 2021.
Moldoveanu Z., H. Suzuki, C. Reily, K. Satake, L. Novak, N. Xu, Z.Q. Huang, B. Knoppova, A. Khan, S. Hall, H. Yanagawa, R. Brown, C.J. Winstead, D.B. O'Quinn, A. Weinmann, A.G. Gharavi, K. Kiryluk, B.A. Julian, C.T. Weaver, Y. Suzuki, and J. Novak. Experimental evidence of pathogenic role of IgG autoantibodies in IgA nephropathy. J. Autoimmun. 118:102593, 2021.
C.T. Weaver. One road to the TH17 pathway: How TH1 led to TH17 (and vice versa), and first became last. Nature Immunology 21:819-821, 2020.
Camacho, V., V.R. Matkins, S.B. Patel, J.M.Lever, Z. Yang, L. Ying, A.E. Landuyt, E.C. Dean, J.F. George, H. Yan, P.B. Ferrell, C.L. Maynard, C.T. Weaver, H.R. Turnquist, and R.S. Welner. Bone marrow Tregs mediate stromal cell function and support hematopoiesis via IL-10. J. Clin. Invest. Insight 5:e135681, 2020.
Harbour, S.N., D.F. DiToro, S.J. Witte, C.L. Zindl, T.R. Schoeb, G.W. Jones, S.A. Jones, R.D. Hatton, and C.T. Weaver. Th17 cells require ongoing classical IL-6 receptor signaling to retain transcriptional and functional identity. Science Immunology 5:eeaw2262, 2020.
DiToro, D.F., S.N. Harbour, Steven Witte, Vincent Laufer, M. Gao, C.E. Moseley1, H. Turner, J. Bruning, C.H. Conover,, R.D. Hatton, S.J. Frank5, and C.T. Weaver. Insulin-like growth factors are key regulators of Th17-Treg cell balance in autoimmunity. Immunity 52:650-667, 2020.
Evonuk, K.S., R.E. Doyle, C.E. Moseley, I.M. Thornell, K. Adler, A.M. Bingaman, M.O. Bevensee, B. Min, C.T. Weaver, and T.M. DeSilva. Reduction of AMPA receptor activity on mature oligodendrocytes attenuates loss of myelinated axons in autoimmune neuroinflammatyion. Sci Adv 6:eaax5936, 2020.
Photo: Immunofluorescence photomicrograph demonstrating the intestinal niche of Nippostrongylus brasiliensis, a hookworm that colonizes the mouse gut and is used to model gastrointestinal nematode infections in humans. Photo Credit: Herbert laboratory, University of Pennsylvania School of Veterinary Medicine.